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  • In this Review, Denoth-Lippuner and Jessberger present recent insights into adult hippocampal neurogenesis in rodents — from stem cell activation to the integration of newborn neurons into pre-existing circuits — and describe how newborn neurons affect brain function.

    • Annina Denoth-Lippuner
    • Sebastian Jessberger
    Review Article
  • Stressful experience increases erroneous choices in a reward-based learning task by weakening excitatory synapses in the lateral habenula via a reduction in AMPA-receptor-mediated synaptic transmission.

    • Sian Lewis
    Research Highlight
  • Inactivation of the gene encoding fragile X mental retardation protein (FMRP) drives the impairments in brain development and function that underlie fragile X syndrome. Richter and Zhao illustrate how innovative genetic and molecular biology tools have enhanced our understanding of both FMRP’s function and the causes of fragile X syndrome pathophysiology.

    • Joel D. Richter
    • Xinyu Zhao
    Review Article
  • A neuroprosthetic baroreflex can restore haemodynamic stability in models of acute and chronic spinal cord injury.

    • Katherine Whalley
    Research Highlight
  • Activity in different parts of the mouse striatum is faithfully predicted by topographically connected areas of cortex.

    • Natasha Bray
    Research Highlight
  • Projections from the anterior cingulate cortex to the nucleus accumbens are required for the social transfer of pain or analgesia in mice.

    • Darran Yates
    Research Highlight
  • Flexibility is critical for the optimal adaptation of thoughts and actions under changing circumstances. In this Review, Uddin summarizes research that has identified cognitive processes and neural systems supporting flexibility and discusses ways to improve flexibility across the lifespan.

    • Lucina Q. Uddin
    Review Article
  • A substantial burden of neurological disease is related to mutations in three sodium channel genes: SCN1A, SCN2A and SCN8A. In this Review, Meisler and colleagues discuss the neurological disorders associated with these mutations and also the therapeutic opportunities that are being investigated as a result of these recent mechanistic insights.

    • Miriam H. Meisler
    • Sophie F. Hill
    • Wenxi Yu
    Review Article
  • The role of the default mode network (DMN) is unclear. In this Perspective, Yeshurun, Nguyen and Hasson review evidence that the DMN integrates extrinsic inputs with intrinsic information over long timescales, enabling it to represent meaning in a way that can be shared between individuals.

    • Yaara Yeshurun
    • Mai Nguyen
    • Uri Hasson
    Perspective
  • In flies, neurons that are common to both sexes regulate aggressive approach, whereas other, sex-specific neurons control attack behaviours.

    • Natasha Bray
    Research Highlight
  • The innate responses of mice to sweet-tasting or bitter-tasting stimuli can be modulated by top-down feedback from the cortex.

    • Katherine Whalley
    Research Highlight
  • Lewy bodies, which are α-synuclein-rich intracellular inclusions, are pathological hallmarks of several neurodegenerative diseases, notably Parkinson disease. In this Review, Fares, Jagannath and Lashuel examine the biochemical, structural and morphological features of Lewy bodies as well as how α-synuclein pathology may form and spread.

    • Mohamed Bilal Fares
    • Somanath Jagannath
    • Hilal A. Lashuel
    Review Article
  • The molecular basis of trans-synaptic signalling by Neurexins plays an important role in synapse organization. In this Review, Scheiffele and colleagues link cell type-specific alternative splicing to the combinatorial action of Neurexin isoforms, and provide a mechanistic framework for Neurexin functions in synapse organization.

    • Andrea M. Gomez
    • Lisa Traunmüller
    • Peter Scheiffele
    Review Article
  • A new study provides evidence suggesting that SARS-CoV-2 may be able to enter the CNS via the neural–mucosal interface in the olfactory mucosa.

    • Darran Yates
    Research Highlight