The convergence of several pathways

Key genes and convergent pathogenic mechanisms in Parkinson disease

  • Robert Coukos
  • Dimitri Krainc
Review Article


    • Slowing neurodegeneration is the most pressing clinical need for multiple sclerosis (MS). In this Review, Woo, Engler and Friese provide a neuron-centric view on inflammation-induced neurodegeneration in MS and discuss key pathways and molecules that can be therapeutically targeted.

      • Marcel S. Woo
      • Jan Broder Engler
      • Manuel A. Friese
      Review Article
    • At early developmental stages, spontaneous activity in the mammalian cortex is characterized by the occurrence of highly synchronous network events. Portera-Cailliau and colleagues describe these activity patterns, their underlying mechanisms and function, and their transition to the desynchronized activity observed in adult individuals.

      • Michelle W. Wu
      • Nazim Kourdougli
      • Carlos Portera-Cailliau
      Review Article
    • A clinically viable speech neuroprosthesis could restore natural speech to individuals with vocal-tract paralysis. In this Review, Silva et al. discuss rapid progress in neural interfaces and computational algorithms for decoding speech from cortical activity and propose evaluation metrics to help standardize speech neuroprostheses.

      • Alexander B. Silva
      • Kaylo T. Littlejohn
      • Edward F. Chang
      Review Article
    • The location-specific firing of hippocampal place cells changes when an animal enters a new environment, a phenomenon known as ‘remapping’. In this Perspective, André A. Fenton challenges standard models of place cell remapping and proposes a key role for the ‘re-registration’ of internally organized place cell population dynamics in the encoding of distinct environments.

      • André A. Fenton
    • Many cognitive functions rely on the ability to link distinct but related memories, while retaining the capacity to recall the individual details of the linked memories. Inokuchi and colleagues describe evidence that memory linking involves engram overlap and discuss the mechanisms that regulate this process.

      • Ali Choucry
      • Masanori Nomoto
      • Kaoru Inokuchi
      Review Article
  • A subset of female mice that show anxiety-related traits seek out a starvation-like state when exposed to repeated stress

    • Katherine Whalley
    Research Highlight
  • The main direction of motor skill-specific information between rat primary motor cortex and dorsolateral striatum is shown to switch from cortex-predominant before learning to striatum-predominant after learning.

    • Sian Lewis
    Research Highlight
  • A large network of brain regions is involved in salient distractor processing.

    • Isobel Leake
    Research Highlight

Nature Careers

Science jobs

  • Postdoctoral fellow at Cherqui Lab, UCSD

    The position focuses on the use of hematopoietic stem and progenitor cells (HSPCs) and gene therapy for neurodegenerative disorders.

    Cherqui Lab, UCSD, La Jolla

    Univesity of California, San Diego

  • PhD/master's Candidate

    PhD/master's Candidate    Graduate School of Frontier Science Initiative, Kanazawa University is seeking candidates for PhD and master's students i...

    Japan (JP)

    Kanazawa University

  • Faculty Positions at SUSTech School of Medicine

    SUSTech School of Medicine offers equal opportunities and welcome applicants from the world with all ethnic backgrounds.

    Shenzhen, Guangdong, China

    Southern University of Science and Technology, School of Medicine

  • Assistant Professor

    Tenure-track Assistant Professor position in the Cell and Molecular Physiology Department at Loyola University Chicago Stritch School of Medicine.

    Maywood, Illinois

    Loyola University of Chicago - Cell and Molecular Physiology Department

  • Faculty Positions in Neurobiology, Westlake University

    We seek exceptional candidates to lead vigorous independent research programs working in any area of neurobiology.

    Hangzhou, Zhejiang, China

    School of Life Sciences, Westlake University