Neural tuning and representational geometry

  • Nikolaus Kriegeskorte
  • Xue-Xin Wei
Perspective

Advertisement

    • Fibroblasts in the CNS have been assigned a role in fibrotic scar formation in response to injury and inflammation but might perform additional roles attributed to other cell types. In this Review, Dorrier and colleagues discuss the available evidence regarding fibroblast functions in the CNS.

      • Cayce E. Dorrier
      • Hannah E. Jones
      • Richard Daneman
      Review Article
    • The encoding of itch by peripheral and central neural circuits is a topic of long-standing interest in the somatosensory field. Here, Zhou-Feng Chen outlines a model for itch coding that emphasizes the role of neuropeptides in conveying itch information from the periphery to the spinal cord.

      • Zhou-Feng Chen
      Perspective
    • The sympathetic regulation of bodily functions relies on precise connections between sympathetic neurons and peripheral organs. In this Review, Scott-Solomon and colleagues discuss the mechanisms underlying the development of the sympathetic nervous system and provide insight into disorders regulated by this branch of the nervous system.

      • Emily Scott-Solomon
      • Erica Boehm
      • Rejji Kuruvilla
      Review Article
    • Male-only studies predominate preclinical research on anxiety and depression. In this Review, Bangasser and Cuarenta discuss how, since the inclusion of female subjects, new mechanisms have been identified that underlie vulnerability to these disorders, and that reveal novel targets for treatments.

      • Debra A. Bangasser
      • Amelia Cuarenta
      Review Article
    • Neural circuits in the mammalian central nervous system are modified in response to neural activity during development. In this Review, Faust and colleagues provide an overview of the mechanisms underlying developmental synaptic pruning and how alterations in this process can occur in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia.

      • Travis E. Faust
      • Georgia Gunner
      • Dorothy P. Schafer
      Review Article
  • Gastrin-releasing peptide (GRP) signalling regulates vasoactive-intestinal peptide (VIP)-expressing cortical cells in a disinhibitory microcircuit that modulates a cortex-dependent behaviour.

    • Jake Rogers
    Research Highlight
  • In a mouse model of mesial temporal lobe epilepsy, reactive hippocampal glia were reprogrammed into functional GABAergic interneurons that integrated into local circuits and reduced seizure incidence.

    • Sian Lewis
    Research Highlight
  • Two studies probe the mechanisms of gene expression regulation that have contributed to human-specific features of the prefrontal cortex.

    • Katherine Whalley
    Research Highlight
  • A new study describes opposing cell-specific RhoA-dependent mechanisms linking the intrinsic regulation of neuronal microtubule dynamics and the extrinsic regulation of reactive astrocyte signalling that restrain axon regeneration.

    • Jake Rogers
    Research Highlight
  • The raphe nucleus contains specific populations of serotonergic neurons that express either orexin type 1 or type 2 receptors that directionally regulate plasma glucose and peripheral energy metabolism.

    • Sian Lewis
    Research Highlight
  • Clathrin undergoes axonal transport as stable ‘packets’, which become more dynamic at synapses.

    • Darran Yates
    Research Highlight
20th Anniversary

20th Anniversary

The October 2020 issue of Nature Reviews Neuroscience marks 20 years since the journal was launched.
Collection

Nature Careers

Events

Jobs