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  • Bayesian optimization is a promising approach towards a more environmentally friendly chemical synthesis, in line with the Sustainable Development Goals. It can aid chemists to explore vast chemical spaces and find green reaction conditions with few experiments, decreasing resource consumption and waste generation while reducing discovery timelines and costs.

    • Elena Braconi
    Comment
  • To improve early-stage research in the field of RNA lipid nanoparticles, there are several best practices to be considered for the collection, interpretation and reporting of characterization data.

    • Omar F. Khan
    Comment
  • To ensure a sustainable future and combat food scarcity, we must boost agricultural productivity, improve climate resilience and optimize resource usage. There is untapped potential for dense wireless sensor networks in agriculture that can increase yields and support resilient production when linked to smart decision and control systems.

    • Peter G. Steeneken
    • Elias Kaiser
    • Marie-Claire ten Veldhuis
    Comment
  • New nanomaterials are being developed for efficient biomolecule delivery to plants. However, detection and quantification of plant cell entry are challenging and currently rely on subjective methods that lack proper controls. The necessary considerations of performing nanoparticle-mediated delivery in plants and how to accurately quantify delivery efficiency are discussed.

    • Gozde S. Demirer
    Comment
  • Laboratory hardware is often custom made or significantly modified. To improve reproducibility, it is imperative that these novel instruments are properly documented. Increasing adoption of open source hardware practices can potentially improve this situation. This article explores how open licences and open development methodologies enable custom instrumentation to be reproduced, scrutinized and properly recorded.

    • Richard W. Bowman
    Comment
  • Logic diagrams are employed in electrical engineering for visualizing switching circuits. However, their utility and applicability extend far beyond the technical sciences. Here, we argue that natural and social scientists alike should consider using logic diagrams in their research. For certain analytical problems, logic diagrams are a perfect fit.

    • Alrik Thiem
    • Zuzana Sebechlebská
    • Lusine Mkrtchyan
    Comment
  • Data analysis relies heavily on computation, and algorithms have grown more demanding in terms of hardware and energy. Monitoring their environmental impacts is and will continue to be an essential part of sustainable research. Here, we provide guidance on how to do so accurately and with limited overheads.

    • Loïc Lannelongue
    • Michael Inouye
    Comment
  • As we close our second volume of Nature Reviews Methods Primers, we look back on our achievements in 2022 and opportunities to better serve our community.

    Editorial