Atomic tip with attached nanoparticles

Tip-enhanced Raman scattering

TERS is used to assess the molecular composition and structure of surfaces to a nanometer scale.


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    Topics soon to be featured include: Holotomography, Spatial multiplexing and omics, Optimal transport for single-cell and spatial omics and STED microscopy.

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  • Tip-enhanced Raman scattering (TERS) can be used to access the molecular composition and structure of surfaces with extreme lateral and depth resolution, down to the nanometre scale and beyond. In this Primer, Höppener et al. discuss the underlying physical principles driving the signal enhancement and lateral resolution of TERS.

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    • Diego Misseroni
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    • Glaucio H. Paulino
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  • Single-case experimental designs are rapidly growing in popularity. This popularity needs to be accompanied by transparent and well-justified methodological and statistical decisions. Appropriate experimental design including randomization, proper data handling and adequate reporting are needed to ensure reproducibility and internal validity. The degree of generalizability can be assessed through replication.

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