Nanozyme in a cage

Nanozymes for nanohealthcare

Artificial enzymes can be prepared from functional nanomaterials for healthcare applications.


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    Topics soon to be featured include: Origami engineering, Metal-organic frameworks, Resonant inelastic X-ray scattering and Tip-enhanced Raman spectroscopy.

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  • Proteoforms can be investigated using top-down proteomics, a technique that analyses whole proteins without previous digestion. This Primer introduces top-down proteomics, exploring mass spectrometry experimental methods, sample preparation, data analysis and applications in understanding human disease.

    • David S. Roberts
    • Joseph A. Loo
    • Ying Ge
  • Nanozymes are nanomaterial-based artificial enzymes that can emulate the catalytic functions inherent in enzymes. In this Primer, Zhang et al. discuss the nanozyme toolbox, including their design and modification, characterization, activity evaluation and applications in healthcare.

    • Yihong Zhang
    • Gen Wei
    • Hui Wei
  • Femtosecond stimulated Raman scattering (FSRS) is an ultrafast pump–probe spectroscopy method for investigating the vibrational dynamics of molecules. In this Primer, Batignani et al. introduce the fundamental concepts behind FSRS, its current utility and future integrations of artificial intelligence and quantum light.

    • Giovanni Batignani
    • Carino Ferrante
    • Tullio Scopigno
  • Solid samples can be imaged and chemically analysed using secondary ion mass spectrometry. This Primer describes the secondary ion mass spectrometry experimental setup, in which a primary ion beam sputters secondary ions that are analysed and detected by a mass spectrometer, and explores applications in materials, geological and life sciences.

    • Nicholas P. Lockyer
    • Satoka Aoyagi
    • Lu-Tao Weng
  • Freeze casting involves directional solidification of solutions or slurries followed by removal of the solid solvent phase. This Primer introduces the freeze casting technique, including experimental and analysis methods, with a particular focus on using X-ray tomoscopy for real-time, 3D observations of freeze casting dynamics.

    • Ulrike G. K. Wegst
    • Paul H. Kamm
    • Francisco García-Moreno
  • Single-case experimental designs are rapidly growing in popularity. This popularity needs to be accompanied by transparent and well-justified methodological and statistical decisions. Appropriate experimental design including randomization, proper data handling and adequate reporting are needed to ensure reproducibility and internal validity. The degree of generalizability can be assessed through replication.

    • René Tanious
    • Rumen Manolov
    • Johan W. S. Vlaeyen
  • Bayesian optimization is a promising approach towards a more environmentally friendly chemical synthesis, in line with the Sustainable Development Goals. It can aid chemists to explore vast chemical spaces and find green reaction conditions with few experiments, decreasing resource consumption and waste generation while reducing discovery timelines and costs.

    • Elena Braconi
  • To improve early-stage research in the field of RNA lipid nanoparticles, there are several best practices to be considered for the collection, interpretation and reporting of characterization data.

    • Omar F. Khan
  • To ensure a sustainable future and combat food scarcity, we must boost agricultural productivity, improve climate resilience and optimize resource usage. There is untapped potential for dense wireless sensor networks in agriculture that can increase yields and support resilient production when linked to smart decision and control systems.

    • Peter G. Steeneken
    • Elias Kaiser
    • Marie-Claire ten Veldhuis
  • New nanomaterials are being developed for efficient biomolecule delivery to plants. However, detection and quantification of plant cell entry are challenging and currently rely on subjective methods that lack proper controls. The necessary considerations of performing nanoparticle-mediated delivery in plants and how to accurately quantify delivery efficiency are discussed.

    • Gozde S. Demirer