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Volume 20 Issue 8, August 2022

‘Hide and seek’ inspired by the Review on p449.

Cover design: Philip Patenall

Research Highlights

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  • A retrospective analysis of seven cases of monkeypox describes virus loads over time and looks at potential management options.

    • Ursula Hofer

    Collection:

    In Brief
  • An analysis of the economic impact of biofilms estimates it at almost US$4,000 billion per year globally.

    • Ursula Hofer
    In Brief
  • This study reports that a short prokaryotic argonaute protein from the archaeon Sulfolobus islandicus and its genetically associated proteins Aga1 and Aga2 confer antiviral defence by abortive infection.

    • Andrea Du Toit
    Research Highlight
  • A single-cell microfluidics study shows that phenotypic heterogeneity and fast growth can reduce antibiotic susceptibility.

    • Ursula Hofer
    In Brief
  • A study in hamsters shows prolonged inflammatory changes after COVID-19.

    • Ursula Hofer
    In Brief
  • A study in mice links a metabolite of the gut microbiota to age-related microglia death.

    • Ursula Hofer
    In Brief
  • Two recent studies highlight the potential of broadly neutralizing monoclonal antibodies for the long-term control of HIV in the absence of antiretroviral therapy.

    • Ashley York
    Research Highlight
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News & Analysis

  • This Genome Watch highlights how metagenomics can fill the knowledge gap of the wild avian gut microbiome and enable the early detection of antibiotic-resistant bacteria with implications for public health policy and conservation management.

    • Physilia Ying Shi Chua
    • Jacob Agerbo Rasmussen
    Genome Watch
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Reviews

  • In this Review, Wang and colleagues review the strategies microbial pathogens use to evade plant immunity for successful infection. They highlight how microbial effectors manipulate host cellular processes involved in immune sensing, signal integration and defence execution and how to exploit this knowledge to engineer crop resistance.

    • Yan Wang
    • Rory N. Pruitt
    • Yuanchao Wang
    Review Article
  • To maintain genome integrity and ensure cell survival, bacteria have evolved several DNA repair pathways to repair different types of DNA damage and non-canonical bases, including strand breaks, nucleotide modifications, cross-links, mismatches and ribonucleotide incorporations. In this Review, Wozniak and Simmons provide a contemporary discussion of the excision-based mechanisms bacteria use to repair the diverse set of lesions they encounter.

    • Katherine J. Wozniak
    • Lyle A. Simmons
    Review Article
  • Combining several antibiotics, either in mixtures or sequential order, is proposed to increase treatment efficacy and reduce resistance evolution. In this Review, Andersson and colleagues discuss the effects of antibiotic combinations, the directional effects of previous antibiotic treatments and the role of stress-response systems as well as the interactions between drugs and resistance mutations.

    • Roderich Roemhild
    • Tobias Bollenbach
    • Dan I. Andersson
    Review Article
  • Chemotaxis is one of the best studied bacterial behaviours, but the underlying mechanisms are much better understood than the reasons and consequences of chemotaxis. In this Review, Keegstra et al. discuss the costs and benefits both for individual bacteria and whole populations.

    • Johannes M. Keegstra
    • Francesco Carrara
    • Roman Stocker
    Review Article
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Amendments & Corrections

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