Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 20 Issue 1, January 2022

Electrifying bacterial physiology, inspired by the Review on p5.

Cover design: Philip Patenall

Volume 20 Issue 1

Research Highlights

  • An experimental evolution study showed that the cost of plasmid carriage can be caused by genetic conflicts between the plasmid and bacterial host chromosome.

    • Ursula Hofer
    In Brief

    Advertisement

  • Bacterial barcoding revealed host bottlenecks and bacterial factors that influence systemic spread of bacterial infections.

    • Ursula Hofer
    In Brief
  • This study shows that segmented filamentous bacteria provide early protection against Citrobacter rodentium via a microbially derived metabolite that primes host innate immunity.

    • Andrea Du Toit
    Research Highlight
  • A recent study provides evidence that the extracellular DNA-based architecture of bacterial biofilms relies on the rare left-handed helical form of DNA known as Z-DNA.

    • Ashley York
    Research Highlight
  • Whether there is overlap between the microbial communities in the gut and oral cavity has been debated. This study found that the salivary and stool microbiomes are highly distinct.

    • Andrea Du Toit
    In Brief
  • The successful treatment of polymicrobial infections is difficult, in part owing to inter-species interactions, which can alter antibiotic susceptibility of the bacteria. This study, focusing on cystic fibrosis, shows that multi-drug resistant Stenotrophomonas maltophilia can provide protection against imipenem to sensitive Pseudomonas aeruginosa.

    • Andrea Du Toit
    In Brief
  • This study describes Mycobacterium leprae infection of western chimpanzees in Côte d’Ivoire and disease manifestation.

    • Andrea Du Toit
    In Brief
Top of page ⤴

News & Analysis

Top of page ⤴

Reviews

  • A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome by the viral enzyme integrase. In this Review, Maertens, Engelman and Cherepanov explore the structure and function of retroviral integrase and how this knowledge is informing the development of integrase inhibitors for the treatment of HIV infection.

    • Goedele N. Maertens
    • Alan N. Engelman
    • Peter Cherepanov
    Review Article
  • In this Review, Avalos and colleagues discuss different aspects of microbial physiology that can have an impact on engineered metabolic pathways, and they describe instances in which natural or engineered physiological traits in host organisms have been harnessed to benefit engineered metabolic pathways for chemical production.

    • José Montaño López
    • Lisset Duran
    • José L. Avalos
    Review Article
  • In this Review, Chevallereau et al. explore the composition and evolution of phage communities as well as their roles in controlling the population and evolutionary dynamics of bacterial communities. They highlight the need for greater ecological realism in laboratory studies to capture the complexity of microbial communities that thrive in natural environments.

    • Anne Chevallereau
    • Benoît J. Pons
    • Edze R. Westra
    Review Article
Top of page ⤴

Search

Quick links