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Volume 19 Issue 5, May 2021

Volume 19 Issue 5

‘Taking a shot at resistance’, inspired by the review article on page 287.

Cover design: Philip Patenall

Research Highlights

  • In Brief |

    This study reports that there is a seasonal transition in soil microbiome composition and functioning in alpine regions and that climate change may alter the timing of this transition and affect biogeochemical cycling and nutrient availability.

    • Grant Otto
  • In Brief |

    This study reports the discovery of an anaerobic ciliate with reduced mitochondria that secondarily acquired a bacterial endosymbiont enabling the host to generate energy by denitrification.

    • Grant Otto
  • In Brief |

    This study reports the development of a skin commensal bacterium as a bacteriotherapy for atopic dermatitis and finds that it is safe and potentially effective in a phase I clinical trial.

    • Grant Otto
  • Research Highlight |

    This study uncovered mutations in core metabolic genes that confer resistance to antimicrobials in clinically relevant pathogens, suggesting that metabolic adaptation may represent a new general mechanism of antimicrobial resistance in bacteria.

    • Ashley York
  • In Brief |

    This study reveals that mites reduce emission of nitrous oxide (N2O) from soil by feeding on N2O-producing fungi, so modulating mite abundance might represent a way to mitigate anthropogenic N2O emissions in agriculture.

    • Grant Otto
  • In Brief |

    This study demonstrates that an N6-methyladenosine (m6A) modification in the internal ribosome entry site of the hepatitis C virus RNA genome affects translation initiation through the action of the m6A reader protein YTHDC2 and its interaction with the La antigen.

    • Grant Otto
  • In Brief |

    This study examines microbial evolution, in the form of biofilm-producing ability, in the context of microbiome ecology and shows that both have an impact on host fitness.

    • Grant Otto
  • Research Highlight |

    This study reports that antigens derived from intracellular bacteria are presented by tumour cells and activate the immune system.

    • Andrea Du Toit

News & Analysis

Reviews

  • Review Article |

    In this Review, Rappuoli and colleagues discuss evidence that vaccines can have a major role in fighting antimicrobial resistance, they describe the current state of development of vaccines against antimicrobial-resistant bacterial pathogens and discuss possible opportunities to overcome obstacles that hinder progress in vaccine development.

    • Francesca Micoli
    • Fabio Bagnoli
    • Davide Serruto
  • Review Article |

    In this Review, Fodor and colleagues discuss recent structural insights into the RNA polymerases of negative-sense RNA viruses and their use to identify novel targets for the development of antiviral agents.

    • Aartjan J. W. te Velthuis
    • Jonathan M. Grimes
    • Ervin Fodor
  • Review Article |

    Bacteria have much more diverse and versatile respiratory chains than eukaryotes, enabling adaption to different environmental conditions. In this Review, Kaila and Wikström discuss the architecture, function and bioenergetics of modular bacterial respiratory chains and supercomplexes.

    • Ville R. I. Kaila
    • Mårten Wikström
  • Review Article |

    Pseudomonas aeruginosa shows high diversity and plasticity, which enables it to succeed in the challenging environment of cystic fibrosis airways. In this Review, Johansen and colleagues highlight genomic and phenotypic adaptation of P. aeruginosa and the implications for infection management.

    • Elio Rossi
    • Ruggero La Rosa
    • Helle Krogh Johansen

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