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Scientists around the world have risen to the challenges posed by COVID-19 by rapidly transforming their laboratories and refocusing their research efforts. In the first of a new series of Feature articles to highlight these efforts, we interviewed three researchers at the Icahn School of Medicine at Mount Sinai.
Two recent studies shed light on the importance of heterogeneity in determining the outcome of influenza virus infections, either by shaping the immune response to infection, or by determining the potential for influenza virus to overcome species barriers.
This study provides structural insides into the mechanism of action of mycobacterial arabinosyltransferases and the mode of action of an anti-tuberculosis drug targeting those enzymes.
This month’s Genome Watch highlights how genomic surveillance can provide important information for identifying and tracking emerging pathogens such as SARS-CoV-2.
Antibiotic persistence is a threat to effective treatment of bacterial infections. In this Review, Bakkeren, Diard and Hardt discuss the evolutionary forces that have favoured the development of persisters in populations and the consequences for spread of resistance and virulence determinants.
Large-scale metagenomic analyses are vastly increasing the rate of discovery of variation within species but they are also leading to scientific and semantic challenges. Bork and colleagues highlight the advances and challenges that are resulting from the use of metagenomic data to study within-species diversity.
In this Review, Lopatkin and Collins discuss key areas of predictive biology that are of growing interest to microbiology, the challenges associated with the innate complexity of microorganisms and the value of quantitative methods in making microbiology more predictable.
In this Review, Ruff, Greiling and Kriegel discuss the mechanisms through which the microbiota contributes to the predisposition, initiation and perpetuation of immune-mediated diseases, and explore the therapeutic avenues that either target the microbiota, the barrier surfaces or the host immune system to restore tolerance and homeostasis.
