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Volume 18 Issue 1, January 2020

‘Rewiring host metabolism’ inspired by the Review on p21.

Cover design: Philip Patenall.

Research Highlights

  • Two recent studies find that pioneering bacterial cells use chemotaxis as a navigation strategy to boost range expansion, but colonizing too quickly can leave the population susceptible to invasion by competitors.

    • Ashley York
    Research Highlight

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  • Further evidence that measles induce ‘immunological amnesia’ highlight the importance of the vaccination and the need to increase vaccination rates.

    • Andrea Du Toit
    Research Highlight
  • A recent study reveals a sequence of molecular events that led to the origin of the most lethal malaria parasite Plasmodium falciparum in humans.

    • Ashley York
    Research Highlight
  • This study identifies a role for members of the endophytic root microbiome and their functional traits in plant protection from the fungal root pathogen Rhizoctonia solani.

    • Andrea Du Toit
    Research Highlight
  • This study shows that surface-attached bacteria modulate flagellar rotation to promote persistence at the surface.

    • Andrea Du Toit
    In Brief
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News & Analysis

  • This month’s Genome Watch article discusses the role of within-host adaptive evolution in bacterial pathogens for colonization and invasion of their human hosts.

    • Chrispin Chaguza
    Genome Watch
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Reviews

  • DNA methylation affects DNA–protein interactions and has important cellular roles, including the control of reversible switching (phase variation) of gene expression. In this Review, Sánchez-Romero and Casadesús review epigenetic signalling by DNA methylation, focusing on its contribution to phenotypic heterogeneity in bacterial populations.

    • María A. Sánchez-Romero
    • Josep Casadesús
    Review Article
  • In this Review, Coleman and colleagues discuss recent advances in understanding the biogeochemical impact of viruses, focusing on how metabolic reprogramming of host cells during viral infection alters the flow of energy and nutrients in aquatic ecosystems.

    • Amy E. Zimmerman
    • Cristina Howard-Varona
    • Maureen L. Coleman
    Review Article
  • In this Review, Jansson and Hofmockel explore the impacts of climate change on soil microorganisms in different climate-sensitive soil ecosystems and the potential ways that soil microorganisms can be harnessed to help mitigate the negative consequences of climate change.

    • Janet K. Jansson
    • Kirsten S. Hofmockel
    Review Article
  • Mycobacterium tuberculosis has a distinctive cell envelope that contributes to its resistance against the human immune system and antibiotic therapy. In this Review, Dulberger, Rubin and Boutte discuss mycobacterial cell envelope dynamics and their relevance for infection and drug treatment.

    • Charles L. Dulberger
    • Eric J. Rubin
    • Cara C. Boutte
    Review Article
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