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Experimental evolution of measles virus reveals that a new phenotype emerges through cooperation between two different viral genomes in a single virion.
The rise of antibiotic resistance, together with collateral damage to the human microbiota as a result of antibiotic use, means that new antimicrobials need to be developed. Here, Cotter, Ross and Hill discuss the potential of bacteriocins, which are active against a range of bacteria, have low toxicity towards the host, are easily modifiable and can even be producedin situ.
In this Progress article, Cossart and colleagues discuss the unique features of unusually long antisense RNAs and discuss the excludon paradigm, which describes a genomic locus that encodes a long antisense RNA which inhibits the expression of one operon while simultaneously driving the expression of the adjacent operon.
Cross-bands in the stalks ofCaulobacter crescentusare composed of at least four proteins and act as diffusion barriers for both soluble and membrane proteins.
A single T3SS effector protein fromS. Typhimurium can expand the narrow host range of S. Typhi by targeting the RAB32-dependent trafficking pathway, which controls the composition of the SCV.
Despite the revolutionary advances made through the application of omic approaches, the importance of studying organisms in pure culture should not be forgotten.
The endoribonuclease RNase E is widespread in bacteria and is crucial for the control of RNA metabolism in the cell. In this Review, George Mackie discusses the role of RNase E in stable RNA processing and mRNA decay, and proposes a new model to reconcile the dynamics of RNA metabolism with the cellular localization of this enzyme.
Repair of double-strand DNA breaks by homologous recombination can be carried out in bacteria by RecBCD, AddAB and AdnAB. Here, Dale Wigley discusses recent insights into how these complexes mediate repair, as well as their evolution.
Sporulation inBacillus subtilisresults in the formation of an endospore surrounded by a multilayered protective structure, known as the coat. In this Review, Patrick Eichenberger and colleagues describe recent studies that have illuminated the architecture of the coat and the dynamics of coat assembly.
Regulated cell death is a key process in plant and animal development, but does it occur in parasitic protozoa? Jeremy Mottram and colleagues assess the evidence of regulated cell death in these organisms and propose that protozoan cell death should be classified as either necrotic or incidental.
