Under the Lens

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  • Under the Lens |

    This month’s Under the Lens discusses the application of high-speed atomic force microscopy to image fragile bacterial membrane vesicles by briefly touching them with a gentle tapping force, revealing species-specific heterogeneity in membrane vesicle size distribution linked to biological function.

    • Ruth Cohen-Khait
  • Under the Lens |

    This month’s Under the Lens discusses dual-view light-sheet microscopy and how its use has revealed the dynamics of bacterial biofilm development, a fundamental process found in bacteria.

    • Suzanne C. Letham
    •  & Tanmay A. M. Bharat
  • Under the Lens |

    This month’s Under the Lens discusses how structural studies of the SARS-CoV-2 spike glycoprotein might guide a path towards a vaccine.

    • Nawsad Alam
    •  & Matthew K. Higgins
  • Under the Lens |

    This month’s Under the Lens discusses recent advances in spatial metabolomics and light-sheet microscopy for imaging the biogeography of host–microbiota interactions.

    • Manish S. Kushwah
    •  & Stephen Thorpe
  • Under the Lens |

    This month’s Under the Lens discusses the use of single-molecule tracking in bacteria to study how CRISPR–Cas systems accurately and efficiently identify specific DNA sequences within viruses and other mobile genetic elements, thereby preventing their invasion.

    • Jarno Mäkelä
    •  & David J. Sherratt
  • Under the Lens |

    This month’s Under the Lens discusses the application of light sheet fluorescence microscopy to observe the intestinal microbiota of live zebrafish, revealing unexpected host–microorganism interactions.

    • Sean C. Booth
    •  & William P. J. Smith
  • Under the Lens |

    This month’s Under the Lens discusses how 3D fluorescence microscopy techniques are furthering the study of dynamic spatial organization and confinement in bacterial cells.

    • Jia Hui Khoo
    •  & Helen L. Miller
  • Under the Lens |

    This month’s Under the Lens discusses the use of a novel label-free imaging method to study pilus dynamics at high spatial and temporal resolution.

    • Samuel J. Hickman
  • Under the Lens |

    This month’s Under the Lens discusses the use of single-molecule tracking to study the effects and response of bacterial cells exposed to antibiotics.

    • Oliver J. Pambos
    •  & Achillefs N. Kapanidis
  • Under the Lens |

    This month’s Under the Lens discusses electron cryotomography (ECT) as a powerful tool for investigating host–pathogen interactions.

    • Emeline Lawarée
    •  & Rafael Custódio
  • Under the Lens |

    This month’s Under the Lens discusses how super-resolution microscopy has been used to answer fundamental questions about the assembly mechanisms of enveloped viruses.

    • Christof Hepp
    •  & Nicole C. Robb
  • Under the Lens |

    This month’s Under the Lens discusses the utility of live-cell fluorescence labelling to record the dynamics of bacterial surface appendages.

    • Valentine Lagage
    •  & Stephan Uphoff*