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In this Review, Chan et al. explore major drug discovery approaches, preclinical antiviral evaluation models, virus-targeting and host-targeting therapeutic strategies, and key treatments currently used in clinical settings for COVID-19.
In this Review, Uberoi, McCready-Vangi and Grice explore the diversity of microorganisms present in wounds and examine the mechanisms through which they invade skin tissues, impair skin repair and cause infection.
In this Review, Snyder et al. discuss the global impacts of food spoilage, mechanisms and causative agents, and strategies and emerging tools to control microbial food spoilage.
In this Review, Pai and colleagues examine the global landscape of drug-resistant tuberculosis, exploring its epidemiology, causes, risk factors, stigma and associated mental health burden as well as discussing the most recent developments in diagnostics, treatment and preventive regimens.
In the Review, Jensen and Unemo examine the epidemiology and clinical features, treatment options, and antimicrobial resistance of Neisseria gonorrhoeae and Mycoplasma genitalium, while briefly covering Chlamydia trachomatis and Treponema pallidum.
In this Review, Jiao, Robinson and colleagues examine recent advances related to the microbial carbon pump, exploring its role in the carbon cycle and climate change, and proposing future research directions and approaches to ocean negative carbon emissions.
In this Review, de Souza and Weaver discuss the potential effects on vector-borne diseases of climate change, weather and other anthropogenic factors, including land use, human mobility and behaviour, as possible contributors to the redistribution of vectors and spread of vector-borne diseases worldwide.
In this Review, Voolstra, Raina, Peixoto and colleagues discuss our current knowledge of the function and role of the bacterial microbiome in coral health and disease, and elucidate the response of the host-associated bacteria to global change, which bears implications for coral reef conservation.
In this Review, Ledvina and Whiteley highlight the key similarities between eukaryotic and bacterial innate immune systems, exploring conserved immune components and signalling strategies, as well as conserved mechanisms for pathogen restriction.
Finding a cure for HIV-1 infection, once considered elusive, now represents a major priority for the global microbiology research community. In this article, Armani-Tourret, Lichterfeld and colleagues highlight recent advances in understanding immunological vulnerabilities of virally infected cells that persist lifelong and represent the major barrier to a cure.
In this Review, Rosenthal, Asua and Conrad summarize our current knowledge of artemisinin partial resistance and focus on the emergence of resistance in Africa, including its epidemiology and transmission dynamics, and mechanisms of resistance.
In this Review, Jones, Marken and Silver develop a conceptual framework for synthetic microbiology organized into three domains — factory, farm and field — to explore the utility of synthetic microbiology in addressing sustainability challenges, and examine several examples of microbial engineering applications relevant to each domain.
In this Review, Thiel and colleagues summarize our emerging knowledge of the SARS-CoV-2 intracellular life cycle and the molecular functions of the viral proteins, as well as their interaction with the host cell.
In this Review, Roussin-Léveillée, Mackey and colleagues examine microorganism interaction with and manipulation of the plant apoplast. Effector-driven extracellular niche establishment is conceptualized as foundational to plant pathogenesis and frames the discussion of the complex interplay between pathogen virulence, host immunity and the physiological dynamics shaping plant–microorganism interactions.
In this Review, Meyerowitz et al. examine the clinical presentations of COVID-19 in the era of widespread population immunity and explore current approaches to managing COVID-19 across different patient groups.
In this study, Ratiner et al. examine the advantages, challenges and future perspectives of utilizing microbiome data in personalized medicine for optimal patient care.
In this Review, Jassey and Jackson explore the intricate relationship between viruses and the autophagic pathway, highlighting how viruses either exploit or manipulate the autophagy pathway to influence their replication and survival within host cells.
In this Review, Tan and colleagues highlight recent efforts to discover non-traditional antimicrobials and explore the therapeutic potential of antimicrobial peptides and macrocycles, antibodies, bacteriophages and antisense-based therapeutics, focusing on how current research efforts are pushing these technologies towards clinical implementation.
In this Review, Motta and Moran explore recent research investigating the role of the gut microbiota in honeybee biology and health, as well as the environmental factors that can impair the microbiota and the potential strategies to restore a perturbed microbiota in honeybees.
In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine learning in microbiology research.
