Research Highlights in 2010

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  • A new paper reports that theVibrio choleraetype VI secretion system can target both eukaryotic and bacterial cells.

    • Cesar Sanchez
    Research Highlight

  • Contact-dependent growth inhibition systems are widespread among Gram-negative bacteria, display distinct mechanisms of action and have roles in intraspecies competition.

    • Andrew Jermy
    Research Highlight

  • A new paper inPLoS Pathogens on Streptococcus pneumoniaepneumolysin provides the first example of the involvement of the NLRP3 inflammasome in protection against a Gram-positive bacterium.

    • Sheilagh Molloy
    Research Highlight

  • Pathogens utilize the sugar that is transported by a newly identified family of sugar transporters and, in some cases, induce the expression of these transporters.

    • Christiaan van Ooij
    Research Highlight

  • A new paper reports that the emergence of a more virulent strain of A/H1N1 pandemic influenza can occur by spontaneous mutations and re-assortment with seasonal viruses.

    • Cesar Sanchez
    Research Highlight

  • A mutualistic relationship between arbuscular mycorrhizal fungi and a member of the most ancient clade of land plants promotes carbon uptake, growth and asexual reproduction in the plant.

    • Andrew Jermy
    Research Highlight

  • Comet tail formation inRickettsiaspp. relies on the formin-like protein Sca2 to mediate actin nucleation.

    • Andrew Jermy
    Research Highlight

  • Variation in the composition of the adult microbiota is shaped not only by environmental factors but also by host genetic components.

    • Andrew Jermy
    Research Highlight

  • Proteins known to protect plants from pathogens also play a part in initiating the interaction of plants with symbionts.

    • Christiaan van Ooij
    Research Highlight

  • Salmonella entericausurps a mechanism for homeostatic turnover of gastrointestinal epithelial cells in order to ensure host cell exit.

    • Sheilagh Molloy
    Research Highlight

  • HSV-1 latency is maintained by a host cell signalling pathway activated by NGF.

    • Rachel David
    Research Highlight

  • A recent paper inMolecular Microbiology sheds new light on the involvement of MxiC in the regulation of secretion through the Shigella flexneritype III secretion system.

    • Sheilagh Molloy
    Research Highlight

  • A new paper in theISME Journalprovides the first evidence for a role of a bacterial type III secretion system (T3SS) in an interaction between a bacterium and a fungus.

    • Sheilagh Molloy
    Research Highlight

  • A new paper inPLoS Biology reveals the mechanism used by the apicomplexan parasite Theileria annulatato usurp the host cell mitotic apparatus.

    • Sheilagh Molloy
    Research Highlight

  • Influenza buds by an ESCRT-independent mechanism that involves the matrix protein M2.

    • Rachel David
    Research Highlight

  • Two articles identify the metabolic niches of two pathogens that provide them with a growth advantage.

    • Christiaan van Ooij
    Research Highlight

  • The identification and characterization of bacterial lipid rafts and their role in the signalling pathways that regulate biofilm formation inBacillus subtilis.

    • Andrew Jermy
    Research Highlight

  • A screen for host factors involved in the formation of the dengue virus replication complex reveals links to localized fatty acid biosynthesis

    • Andrew Jermy
    Research Highlight

  • Vibrio parahaemolyticusVPA0450 contributes to host cell death by interfering with phosphatidylinositol signalling.

    • Rachel David
    Research Highlight

  • The vitamin B6-dependent glycosylation of flagella is required for full Helicobacter pylorimotility and virulence.

    • Sheilagh Molloy
    Research Highlight