Review Articles

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  • Haldar and colleagues discuss markers and mechanisms of resistance to artemisinins and artemisinin-based combination therapies. They describe the identification ofPlasmodium falciparum Kelch 13 as the primary and, to date, sole causative marker of artemisinin resistance in P. falciparumand explore two proposed resistance mechanisms. They emphasize continuing challenges to improve detection strategies and new drug development strategies.

    • Kasturi Haldar
    • Souvik Bhattacharjee
    • Innocent Safeukui
    Review Article
  • Our skin is home to millions of bacteria, fungi and viruses that comprise the skin microbiota. In this Review, Byrd and colleagues discuss recent insights into skin microbial communities, including their composition in health and disease, dynamics between species and interactions with the immune system.

    • Allyson L. Byrd
    • Yasmine Belkaid
    • Julia A. Segre
    Review Article
  • The interplay between nutrient intake, gut microbial metabolism and microorganism-driven engagement of host receptors contributes to the pathogenesis of cardiovascular disease. In this Review, Brown and Hazen discuss the gut microbial mechanisms that drive cardiovascular disease, with special emphasis on therapeutic interventions.

    • J. Mark Brown
    • Stanley L. Hazen
    Review Article
  • Recently, virulence mechanisms beyond canonical drug resistance were uncovered that enableAcinetobacter baumanniito thrive in the health-care environment and cause infections in critically ill patients. Harding, Hennon and Feldman explore the molecular features that promote environmental persistence and the most recently identified virulence factors that enable successful human infection.

    • Christian M. Harding
    • Seth W. Hennon
    • Mario F. Feldman
    Review Article
  • In this Review, Husnik and McCutcheon discuss how horizontally transferred genes from bacteria become functional in eukaryotes and classify horizontal gene transfer events into two broad types: those that maintain pre-existing functions and those that add new functionality to the recipient, including altered host nutrition, protection and adaptation to extreme environments.

    • Filip Husnik
    • John P. McCutcheon
    Review Article
  • One of the most prominent features of archaea is the extraordinary diversity of their viruses. In this Review, Prangishviliet al. summarize their morphological diversity, the molecular biology of their life cycles and virus–host interactions, and discuss their evolution and their role in the global virosphere.

    • David Prangishvili
    • Dennis H. Bamford
    • Mart Krupovic
    Review Article
  • The Archaea was recognized as a third domain of life 40 years ago. In this Review, Emeet al. outline a brief history of the changing shape of the tree of life and examine how the recent discovery of diverse archaeal lineages has changed our understanding of the evolutionary relationships between the three domains of life and the origin of the eukaryotic cell.

    • Laura Eme
    • Anja Spang
    • Thijs J. G. Ettema
    Review Article
  • Co-infection withMycobacterium tuberculosisis the leading cause of death in individuals infected with HIV-1. In this Review, Bell and Noursadeghi describe the epidemiological associations between the two pathogens, selected interactions of each pathogen with the host and our current understanding of how they affect the pathogenesis of tuberculosis and HIV-1/AIDS in individuals with co-infection.

    • Lucy C. K. Bell
    • Mahdad Noursadeghi
    Review Article
  • Seasonal influenza viruses continue to cause epidemics each year. In this Review, Petrova and Russell discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus control.

    • Velislava N. Petrova
    • Colin A. Russell
    Review Article
  • The ability ofCandida albicans to form biofilms is a major cause of disseminated bloodstream infections. Here, Nobile and colleagues review our current understanding of the processes involved in the formation of C. albicans biofilms, the core transcriptional network that regulates biofilm development, and polymicrobial biofilms that are formed by C. albicansand certain bacterial species.

    • Matthew B. Lohse
    • Megha Gulati
    • Clarissa J. Nobile
    Review Article
  • In this Review, Stoodley and colleagues discuss current therapeutic strategies and those under development for the treatment of pathogenic biofilms. They explore novel technologies that promise to enhance the efficacy of current therapeutics or provide novel effects and argue that treating biofilm infections requires combination therapies.

    • Hyun Koo
    • Raymond N. Allan
    • Luanne Hall-Stoodley
    Review Article
  • Aspergillus fumigatusis an environmental fungus that can cause life-threatening disease. In this Review, van de Veerdonk and colleagues describe howA. fumigatusadapts to environmental change, mechanisms of host defence and our current knowledge of the interplay between the host immune response and the fungus.

    • Frank L. van de Veerdonk
    • Mark S. Gresnigt
    • Jean-Paul Latgé
    Review Article
  • Apicomplexa include important human pathogens and possess a unique cellular machinery that promotes gliding motility and is called the glideosome. In this Review, Soldati-Favre and colleagues discuss the principles that govern gliding motility, the characterization of the molecular machinery that comprises the glideosome, and its impact on parasite invasion and egress from infected cells.

    • Karine Frénal
    • Jean-François Dubremetz
    • Dominique Soldati-Favre
    Review Article
  • Soil contains a vast diversity of microorganisms that can directly or indirectly modulate soil processes and terrestrial ecosystems. In this Review, Fierer summarizes the challenges in characterizing the composition and functions of the soil microbiome, and discusses key future research directions.

    • Noah Fierer
    Review Article
  • It is remarkable how robustly a bacterial species can maintain its preferred size. In this Review, Willis and Huang explore classic and current knowledge of the mechanisms that coordinate bacterial cell size with essential growth and cell cycle processes.

    • Lisa Willis
    • Kerwyn Casey Huang
    Review Article
  • The fungal kingdom contains many important plant pathogens, and some species show remarkable variation in genome size and architecture. In this Review, Möller and Stukenbrock summarize key examples from fungal plant pathogen genomics and discuss evolutionary processes in pathogenic fungi in the context of molecular evolution, population genetics and agriculture.

    • Mareike Möller
    • Eva H. Stukenbrock
    Review Article
  • The intracellular pathogensLegionella pneumophila and Coxiella burnetiiuse the Dot/Icm type IV secretion system to translocate effectors into host cells. Qiu and Luo explore the biochemical and cell biological functions of these effectors and their roles in our understanding of bacterial virulence.

    • Jiazhang Qiu
    • Zhao-Qing Luo
    Review Article
  • The release of membrane-bound vesicles from cells is being increasingly recognized as a mechanism of intercellular communication. In this Review, Raab-Traub and Dittmer discuss the roles that extracellular vesicles have during virus infection.

    • Nancy Raab-Traub
    • Dirk P. Dittmer
    Review Article