Genome Watch

This month's Genome Watch highlights how sequencing the genomes of multiple bacterial isolates from humans and animal infection models has revealed the presence of mutations that might represent adaptations for persistence in the host.

This month's Genome Watch highlights how metagenomics is continuing to reveal the diversity of microorganisms in the environment and how it is challenging and expanding our understanding of how life evolved on Earth.

This month's Genome Watch highlights how culture-independent selective enrichment approaches are now being coupled to whole-genome sequencing to enable the analysis of unculturable microorganisms.

This month's Genome Watch explores howin vitro directed evolution can be used to identify the target of a drug for the treatment of Chagas disease, which is caused by Trypanosoma cruzi.

This month's Genome Watch discusses the potential of selective whole-genome amplification for overcoming the challenges of whole-genome sequencing of malaria parasites in clinical samples in which they are low in abundance.

This month's Genome Watch discusses how whole-genome sequencing of bacteria from several body sites has provided insights into the spatial diversity of bacteria within patients.

This month's Genome Watch describes how whole-genome sequencing used for surveillance purposes has enabled the identification of new drug resistance markers in the malaria parasite.

This month's Genome Watch describes how Mash can be used to tackle comparisons between large amounts of genomic and metagenomic sequence data for taxonomic applications.

This month's Genome Watch discusses how advances in genome editing have contributed to our understanding of apicomplexan parasite biology.

Whole-genome sequencing (WGS) can be used to track the transmission of Neisseria gonorrhoeae in different sexual networks.

This month's Genome Watch explores recent advances in the identification of species-level and strain-level diversity in microbiome studies, and highlights how these have provided insights into the tropism and persistence ofNeisseriaspp. in the human oral cavity.

How did a gorilla-infectingPlasmodiumspecies jump to a human host?

This month's Genome Watch discusses recent improvements to bacterial GWAS methods that have been inspired by techniques developed for human genetics.

Two recent studies have investigated the effects of antibiotic use on the intestinal microbiota of preterm infants and young children.

This month's Genome Watch looks at how genome sequence analysis aids our understanding of pathogen survival within hosts.

Genomics studies are prompting a re-evaluation of the diversity ofEscherichia colipathovars and how this diversity corresponds to virulence.

This month's Genome Watch discusses the analysis of aHelicobacter pylorigenome from the preserved Copper-Age mummy known as the Iceman and how ancient genomes shed light on the history of bacterial pathogens.

The analysis of mammalian genomes provides new insights into the interactions of endogenous retroviruses with other viruses and their hosts.

Functional genomics has helped to identify global regulators of sexual differentiation in the malaria parasite.

This month's Genome Watch highlights how single-cell transcriptomic analysis of infected macrophages has provided insight into the diversity in host–pathogen interactions.