Genome Watch

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  • This month’s Genome Watch discusses how a better understanding of the genetic mechanisms of antimalarial drug resistance can maximize the utility of genomic surveillance programs in informing the most effective drug policy.

    • Gavin G. Rutledge
    • Roberto Amato
    Genome Watch
  • This month's Genome Watch highlights how a better understanding of genotype–phenotype correlation may lead to the design of new diagnostic tests for antimicrobial resistance in clinical settings.

    • Stephanie W. Lo
    • Narender Kumar
    • Nicole E. Wheeler
    Genome Watch
  • This month's Genome Watch discusses the detailed analysis of the human 'archaeome' from various body sites and highlights how current sequencing methods underestimate archaeal diversity and abundance.

    • Lindsay J. Pike
    • Samuel C. Forster
    Genome Watch
  • This month's Genome Watch highlights how genomics has improved our understanding of how vaccines impact pathogen populations and their genomes.

    • Eva Heinz
    Genome Watch
  • This month's Genome Watch examines how coupling deep sequencing of the gut microbiome with metabolic profiles can advance the development of microbiota-focused personalized precision nutrition.

    • Elisa Viciani
    Genome Watch
  • This month's Genome Watch discusses the release of 1,003 bacterial and archaeal genomes, and describes how they could increase our understanding of the diversity of microbial biological functions and contribute to improved metagenomic analyses.

    • Samuel C. Forster
    Genome Watch
  • This month's Genome Watch discusses how genome-wide epistasis analysis and genome-to-genome analyses are providing insights into the relevance of interactions between and within genomes of pathogens and their hosts.

    • John A. Lees
    • Gerry Tonkin-Hill
    • Stephen D. Bentley
    Genome Watch
  • This month's Genome Watch highlights how sequencing the genomes of multiple bacterial isolates from humans and animal infection models has revealed the presence of mutations that might represent adaptations for persistence in the host.

    • Chrispin Chaguza
    • Stephen D. Bentley
    Genome Watch
  • This month's Genome Watch highlights how metagenomics is continuing to reveal the diversity of microorganisms in the environment and how it is challenging and expanding our understanding of how life evolved on Earth.

    • Eva Heinz
    • Daryl Domman
    Genome Watch
  • This month's Genome Watch highlights how culture-independent selective enrichment approaches are now being coupled to whole-genome sequencing to enable the analysis of unculturable microorganisms.

    • Isobel Everall
    • Leonor Sánchez-Busó
    Genome Watch
  • This month's Genome Watch explores howin vitro directed evolution can be used to identify the target of a drug for the treatment of Chagas disease, which is caused by Trypanosoma cruzi.

    • Alena Pance
    Genome Watch
  • This month's Genome Watch discusses the potential of selective whole-genome amplification for overcoming the challenges of whole-genome sequencing of malaria parasites in clinical samples in which they are low in abundance.

    • Gavin G. Rutledge
    • Cristina V. Ariani
    Genome Watch
  • This month's Genome Watch discusses how whole-genome sequencing of bacteria from several body sites has provided insights into the spatial diversity of bacteria within patients.

    • Samuel E. Kidman
    • Josephine M. Bryant
    Genome Watch
  • This month's Genome Watch describes how whole-genome sequencing used for surveillance purposes has enabled the identification of new drug resistance markers in the malaria parasite.

    • Gavin G. Rutledge
    • Thomas D. Otto
    Genome Watch
  • This month's Genome Watch describes how Mash can be used to tackle comparisons between large amounts of genomic and metagenomic sequence data for taxonomic applications.

    • Silvia Argimón
    • David M. Aanensen
    Genome Watch
  • This month's Genome Watch discusses how advances in genome editing have contributed to our understanding of apicomplexan parasite biology.

    • Manuela Carrasquilla
    • Christian K. Owusu
    Genome Watch
  • Whole-genome sequencing (WGS) can be used to track the transmission of Neisseria gonorrhoeae in different sexual networks.

    • Leonor Sánchez-Busó
    • Simon R. Harris
    Genome Watch
  • This month's Genome Watch explores recent advances in the identification of species-level and strain-level diversity in microbiome studies, and highlights how these have provided insights into the tropism and persistence ofNeisseriaspp. in the human oral cavity.

    • James Hadfield
    • Sophia David
    Genome Watch
  • How did a gorilla-infectingPlasmodiumspecies jump to a human host?

    • William R. Proto
    Genome Watch
  • This month's Genome Watch discusses recent improvements to bacterial GWAS methods that have been inspired by techniques developed for human genetics.

    • John A. Lees
    • Stephen D. Bentley
    Genome Watch