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  • In this Review, Georjon and Bernheim provide an overview of the molecular diversity of the most recently discovered bacterial antiphage defence systems and discuss their evolution and the ecological impact of their diversity.

    • Héloïse Georjon
    • Aude Bernheim
    Review Article
  • In this Review, Langedijk and Bont discuss our current understanding of respiratory syncytial virus (RSV) burden of disease, virus biology and pathogenesis, and host and viral factors related to immunity as a segue towards the development of novel RSV interventions.

    • Annefleur C. Langedijk
    • Louis J. Bont
    Review Article
  • In this study, Gül et al. show that usage of different carbon sources by Enterobacteriaceae strains determines their expansion and co-existence in the mouse gut and favours plasmid transfer.

    • Agustina Taglialegna
    Research Highlight
  • The study reveals how a satellite phage-encoded protein directs the assembly of coat proteins into small capsids.

    • Andrea Du Toit
    Research Highlight
  • In this study, Tsuji et al. report the glycolipid 7DW8-5 that exploits the host innate immune system to control SARS-CoV-2, respiratory syncytial virus and influenza virus infections.

    • Agustina Taglialegna
    Research Highlight
  • The authors developed a refillable, long-acting subcutaneous nanofluidic antiretroviral delivery implant that conferred protection against infection with simian–human immunodeficiency virus in rhesus macaques.

    • Andrea Du Toit
    Research Highlight
  • In this study, Douglas et al. examine the role of the staphylococcal TcaA protein in human serum susceptibility during bacteraemia.

    • Agustina Taglialegna
    Research Highlight
  • In this study, Irazoki et al. show that Vibrio cholerae releases d-amino acids into the environment, which are sensed by a bacterial chemoreceptor to prompt a repellent chemotactic response.

    • Agustina Taglialegna
    Research Highlight
  • This study provides insights into the mechanism whereby Citrobacter rodentium transitions from the intestinal lumen to its mucosal niche.

    • Andrea Du Toit
    Research Highlight
  • In this Review, Castañeda-Barba, Top and Stalder use the One Health framework to synthesize the recent literature on the ecological and evolutionary factors that determine the successful local and global spread of plasmid-mediated antimicrobial resistance genes.

    • Salvador Castañeda-Barba
    • Eva M. Top
    • Thibault Stalder
    Review Article
  • In this Review, Porter and Sullivan examine how Wolbachia interact with diverse host cellular components driving the endosymbiont’s global spread and discuss strategies to exploit Wolbachia for insect-based and parasite-based disease control.

    • Jillian Porter
    • William Sullivan
    Review Article
  • This Genome Watch highlights new computational approaches aimed at circumventing contamination in low-biomass microbiome studies.

    • Yan Shao
    Genome Watch
  • In this Review, Xu, Gu and Lovley examine the varied mechanisms by which microorganisms can cause metal corrosion and explore different strategies that could prevent it.

    • Dake Xu
    • Tingyue Gu
    • Derek R. Lovley
    Review Article
  • In this Review, Landovitz, Scott and Deeks explore the current state of the art for HIV prevention and treatment, including unmet needs and emerging tools. They describe how researchers are combining different approaches, such as prevention, treatment and cure, to achieve better outcomes in the fight against the HIV/AIDS epidemic.

    • Raphael J. Landovitz
    • Hyman Scott
    • Steven G. Deeks
    Review Article
  • This study suggests that pre-existing DENV immunity has a negative effect on the pathogenesis of secondary ZIKV infection during pregnancy in marmosets.

    • Andrea Du Toit
    Research Highlight
  • This study reveals the conformational changes of the utilisome that facilitate glycan processing and import.

    • Andrea Du Toit
    Research Highlight
  • This study reports that an engineered bee symbiont provides protection against Nosema ceranae infection.

    • Andrea Du Toit
    Research Highlight