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  • Mazzolini and colleagues have developed an engineered Mycoplasma pneumoniae strain to treat and prevent Pseudomonas aeruginosa infections in the lung.

    • Agustina Taglialegna
    Research Highlight
  • In this Review, Howden and co-workers examine and integrate recent key advances in understanding the mechanisms that Staphylococcus aureus uses to cause infections.

    • Benjamin P. Howden
    • Stefano G. Giulieri
    • Timothy P. Stinear
    Review Article
  • Yang et al. present the fluorogenic reversible reporter SURF to monitor real-time interactions between the SARS-CoV-2 spike protein and ACE2, and identify compounds that block such interaction.

    • Agustina Taglialegna
    Research Highlight
  • In this Review, the authors summarize the mutations harboured by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern. They describe the impact of mutations on virus infectivity and transmissibility, and discuss SARS-CoV-2 evolution in the context of T cells, innate immunity and population immunity.

    • Alessandro M. Carabelli
    • Thomas P. Peacock
    • David L. Robertson
    Review Article
  • This study reports that Acinetobacter baumannii establishes intracellular reservoirs in the bladder that can seed recurrent infections following catheterization.

    • Andrea Du Toit
    Research Highlight
  • Choi et al. demonstrate there is a mutualistic interaction between Pseudomonas aeruginosa and cancer cells that modulates tumour homeostasis.

    • Agustina Taglialegna
    Research Highlight
  • This study reports the finding that the commensal Streptococcus salivarius exacerbates allergic rhinitis.

    • Andrea Du Toit
    Research Highlight
  • A recent study found that the Helicobacter pylori genome evolves during disease progression and that these genomic changes select for effective colonizers of gastric metaplasia.

    • Ashley York
    Research Highlight
  • A recent study reports the development of a biomarker-responsive engineered bacterium that can diagnose, record and treat inflammatory bowel disease in mice.

    • Ashley York
    Research Highlight
  • Long COVID is an often debilitating illness of severe symptoms that can develop during or following COVID-19. In this Review, Davis, McCorkell, Vogel and Topol explore our knowledge of long COVID and highlight key findings, including potential mechanisms, the overlap with other conditions and potential treatments. They also discuss challenges and recommendations for long COVID research and care.

    • Hannah E. Davis
    • Lisa McCorkell
    • Eric J. Topol
    Review Article
  • Xie et al. show that the harmaline metabolite produced by Akkermansia muciniphila modulates nuclear factor-κB signalling and reduces severe fever with thrombocytopenia syndrome severity.

    • Agustina Taglialegna
    Research Highlight
  • In this Review, Minkoff and tenOever examine the relationship between SARS-CoV-2 biology and innate immunity, and they explore how antagonism and dysregulation of host innate immune defences contribute to COVID-19 disease severity.

    • Judith M. Minkoff
    • Benjamin tenOever
    Review Article
  • This Genome Watch explores how metagenomics aids in profiling plant-derived microorganisms and molecules that could have an impact on the composition and function of the human gut microbiome.

    • Karen Serrano
    • Margot Bezrutcyzk
    Genome Watch
  • Thaiss and colleagues report a gut–brain connection in mice that regulates the motivation for exercise, linking the intestinal microbiome to midbrain dopamine signalling.

    • Andrea Du Toit
    Research Highlight
  • This Genome Watch article explores how portable sequencing technology is re-shaping the field of genomic epidemiology.

    • Catherine N. Wilson
    • Patrick Musicha
    • Mathew A. Beale
    Genome Watch
  • Although numerous tick-borne viruses are seemingly apathogenic in humans, a number of emerging tick-borne viruses have been recently identified to possess human-infection potential, with more yet to be discovered. Here, we call for greater research efforts to better delineate their precise disease burden and threats posed to global public health.

    • Hong Zhou
    • Lin Xu
    • Weifeng Shi
    Comment
  • Arevalo et al. have developed a nucleoside-modified mRNA-lipid nanoparticle vaccine encoding separate haemagglutinin antigens from all known influenza virus subtypes.

    • Michael Attwaters
    Research Highlight
  • Meyer et al. show that Toxoplasma gondii infection influences wolf behaviour in the wild, increasing risk-taking behaviours such as dispersing from a pack and becoming a pack leader.

    • Michael Attwaters
    Research Highlight
  • Wu et al. provide mechanistic insight into how the plant symbiotic fungus Metarhizium robertsii can reduce mercury accumulation in soil.

    • Michael Attwaters
    Research Highlight