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  • In this Review, Duffy et al. examine the malaria vaccine landscape, showcasing both achievements and setbacks over the past decades. They discuss approaches and assays for different parasite stages, summarize recent advancements, propose a decision-making process for the field and identify future priorities to address unmet needs.

    • Patrick E. Duffy
    • J. Patrick Gorres
    • Michal Fried
    Review Article
  • This study shows that the anti-CRISPR protein AcrIF25 inhibits the type I-F CRISPR–Cas system by pulling apart the fully assembled Csy complex.

    • Andrea Du Toit
    Research Highlight
  • This study shows that accounting for spillover effects increased the cost-effectiveness of combined malaria-elimination interventions.

    • Andrea Du Toit
    Research Highlight
  • In this study, Diehl et al. report that brilacidin could be a promising antifungal drug against Cryptococcus neoformans.

    • Agustina Taglialegna
    Research Highlight
  • In this study, White et al. report that Alcaligenes faecalis mediates wound repair in diabetic foot ulcers.

    • Agustina Taglialegna
    Research Highlight
  • A WHO report suggests the terms ‘airborne transmission/inhalation’, ‘direct deposition’ and ‘infectious respiratory particles’ for describing transmission modes, highlighting the continuum of particle size with greatest exposure near the source. The report did not update infection control guidelines.

    • Nancy H. L. Leung
    • Donald K. Milton
    Comment
  • In this Review, Brown et al. provide an overview of fungal pathobiology from the pathogen, host and clinical perspectives, focusing specifically on pathogens that can cause invasive life-threatening infections.

    • Gordon D. Brown
    • Elizabeth R. Ballou
    • Duncan Wilson
    Review Article
  • In this Review, Domenech de Cellès and Rohani explore the contemporary epidemiology of pertussis and discuss the controversies surrounding the mechanisms responsible for the re-emergence of pertussis, including the effectiveness and duration of natural immunity and vaccine-derived immunity, the ability of vaccines to prevent transmission and severe disease, and the impact of evolution on evading vaccine immunity.

    • Matthieu Domenech de Cellès
    • Pejman Rohani
    Review Article
  • In this study, Hiis et al. demonstrate that the N2O-respiring bacterial strain Cloacibacterium sp. CB-01 can reduce nitrous oxide emissions from soil.

    • Agustina Taglialegna
    Research Highlight
  • This study shows that archaea produce catalytically active ultraminimal as well as hybrid [FeFe] hydrogenases.

    • Andrea Du Toit
    Research Highlight
  • This Review explores recent insights into the evolutionary history, the environmental adaptation and the colonization and dissemination mechanisms of Enterococcus faecium, and highlight potential novel preventative and therapeutic approaches to its infections.

    • Yahan Wei
    • Dennise Palacios Araya
    • Kelli L. Palmer
    Review Article
  • In this study, Niggs et al. show that Drosophila A virus infection modulates epithelial turnover in the intestine of Drosophila melanogaster, promoting premature intestinal dysplasia and reducing fly lifespan.

    • Agustina Taglialegna
    Research Highlight
  • This study reports that plectasin uses a supramolecular antimicrobial mode of action, whereby the oligomerized peptide sequesters lipid II.

    • Andrea Du Toit
    Research Highlight
  • In this Review, Lyons, Tino and colleagues explore the evolution of microbial life on Earth and examine the diversity of early microbial metabolic pathways, their associations with biogeochemical cycles and how they shaped and responded to changing surface environments over billions of years.

    • Timothy W. Lyons
    • Christopher J. Tino
    • Eva E. Stüeken
    Review Article