In this Review, Mather et al. discuss the role of genome-based approaches in deepening our understanding of both enduring and emerging bacterial foodborne pathogens in the context of evolving global food systems and environmental changes.

In this Review, Sugrue, Ross and Hill explore recent developments in bacteriocin research, including new discoveries and bioengineering approaches for improved activity, and discuss their application in microbiome modulation and clinical potential.

In this Review, Lyons, Tino and colleagues explore the evolution of microbial life on Earth and examine the diversity of early microbial metabolic pathways, their associations with biogeochemical cycles and how they shaped and responded to changing surface environments over billions of years.

A new study reports sustained HIV remission in an individual who underwent allogeneic haematopoietic stem cell transplantation with cells from a donor with wild-type CCR5.

This Genome Watch highlights how the revived interest in phages that target plasmid-carrying bacteria is expanding our knowledge of viral diversity, ecology and evolution, which is fundamental for developing safe biotherapeutics.

This study shows that Citrobacter rodentium alters its growth and virulence in response to varying intestinal pH, and, in turn, the host actively induces stomach acidification.

This Genome Watch highlights recent metagenomic surveys that have revealed the extensive prevalence and diversity of plasmids in the human gut microbiome and discusses the challenges in accurately reporting plasmid genomes identified from metagenomic data.

In this study, Kim, Kang, Jang et al. report a phenotype-based, ultra-rapid and blood culture-free antimicrobial susceptibility testing approach.

In this study, Li, Feng et al. identify an antimicrobial compound produced by plant root-associated Pseudomonas fluorescens with potent activity against drug-resistant, Gram-positive bacteria.