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Envelope stress responses: balancing damage repair and toxicity

Latest Reviews

  • Analysis |

    CRISPR–Cas systems in bacteria and archaea have multifaceted evolutionary relationships with mobile genetic elements (MGEs), including viruses, plasmids and transposons. CRISPR–Cas systems or their components have also been recruited by MGEs on many independent occasions. In this Analysis article, Koonin and colleagues investigate and substantially expand the range of CRISPR–Cas components carried by MGEs.

    • Guilhem Faure
    • , Sergey A. Shmakov
    • , Winston X. Yan
    • , David R. Cheng
    • , David A. Scott
    • , Joseph E. Peters
    • , Kira S. Makarova
    •  & Eugene V. Koonin
  • Review Article |

    In this Review, Reyes-Lamothe and Sherratt describe the contributions of chromosome structure and nucleoid folding to cell cycle regulation, detail the cellular processes involved in the initiation of DNA replication and DNA segregation and explore how those processes are linked to cell growth and cell division.

    • Rodrigo Reyes-Lamothe
    •  & David J. Sherratt
  • Review Article |

    In this Review, Mitchell and Silhavy explore the cellular envelope stress response pathways and discuss what occurs when these pathways are aberrantly activated. They also discuss how recent insights into stress response activation have highlighted the extreme toxicity of unfolded outer membrane proteins.

    • Angela M. Mitchell
    •  & Thomas J. Silhavy
  • Review Article |

    Lipopolysaccharide is a key component of the Gram-negative cell envelope and functions, for example, as a permeability barrier or determinant of host immune responses. In this Review, Simpson and Trent guide us through lipopolysaccharide biogenesis and modifications and their functional and therapeutic implications.

    • Brent W. Simpson
    •  & M. Stephen Trent
  • Perspective |

    The origin of viruses is an unsolved, controversial question. In this Opinion article, Krupovic, Dolja and Koonin propose a new scenario for the origin of viruses based on primordial, selfish replicators acquiring structural proteins from cells, enabling them to form virions.

    • Mart Krupovic
    • , Valerian V. Dolja
    •  & Eugene V. Koonin
  • Perspective |

    In this Opinion article, Sonnenburg and Sonnenburg explore whether individuals in the industrialized world may be harbouring a microbial community that is now incompatible with human biology, and they hypothesize that the modern, industrial lifestyle has contributed to alterations in the microbiota that may be linked to the deterioration of human health.

    • Erica D. Sonnenburg
    •  & Justin L. Sonnenburg

News & Comment

  • Research Highlight |

    A recent study reports that Cas13 induces a state of dormancy in bacteria, which inhibits viral replication and the rise of CRISPR-resistant phages.

    • Ashley York
  • Research Highlight |

    This study shows that bacteria can maintain efficient chemotaxis in the presence of obstacles by reducing their tumbling frequency.

    • Ursula Hofer
  • Genome Watch |

    This month’s Genome Watch highlights the use of genome-centric approaches to further our understanding of the human gut microbiome.

    • Tanja Woyke
  • Research Highlight |

    A recent study reports a force-independent form of flow-sensing in Pseudomonas aeruginosa.

    • Ashley York
  • Viewpoint |

    In this Viewpoint article, several experts discuss the microbial contributions to climate change and consider the effects of global warming, extreme weather and other consequences of climate change on microbial communities in the ocean and soil, host–microbiota interactions and the global burden of infectious diseases and ecosystem processes, and they explore open questions and research needs.

    • David A. Hutchins
    • , Janet K. Jansson
    • , Justin V. Remais
    • , Virginia I. Rich
    • , Brajesh K. Singh
    •  & Pankaj Trivedi
  • Comment |

    Global change microbiology is a rapidly growing research field on microbial responses to global warming, overuse and pollution and on feedback mechanisms and functions that affect Earth’s element cycles and planetary health. In this Comment, Antje Boetius explores how this field could provide essential knowledge and sustainable solutions to the problems driven by global change.

    • Antje Boetius

Collection

Gut Microbiota

Brain light / Alamy Stock Photo

Gut Microbiota

This collection combines published Research articles and Reviews from several Nature journals highlighting recent advances in our understanding of the role of the gut microbiota in health and disease, and the tools for studying these complex communities.

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