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Envelope stress responses: balancing damage repair and toxicity

Latest Reviews

  • Review Article |

    Whole genome sequencing (WGS) offers new opportunities in the clinical management and surveillance of Mycobacterium tuberculosis. In this Review, Meehan and colleagues explore the current landscape of WGS pipelines and applications, and set out best practices for M. tuberculosis WGS, including standards for bioinformatics pipelines, curated repositories of resistance-causing variants, phylogenetic analyses, quality control and standardized reporting.

    • Conor J. Meehan
    • , Galo A. Goig
    • , Thomas A. Kohl
    • , Lennert Verboven
    • , Anzaan Dippenaar
    • , Matthew Ezewudo
    • , Maha R. Farhat
    • , Jennifer L. Guthrie
    • , Kris Laukens
    • , Paolo Miotto
    • , Boatema Ofori-Anyinam
    • , Viola Dreyer
    • , Philip Supply
    • , Anita Suresh
    • , Christian Utpatel
    • , Dick van Soolingen
    • , Yang Zhou
    • , Philip M. Ashton
    • , Daniela Brites
    • , Andrea M. Cabibbe
    • , Bouke C. de Jong
    • , Margaretha de Vos
    • , Fabrizio Menardo
    • , Sebastien Gagneux
    • , Qian Gao
    • , Tim H. Heupink
    • , Qingyun Liu
    • , Chloé Loiseau
    • , Leen Rigouts
    • , Timothy C. Rodwell
    • , Elisa Tagliani
    • , Timothy M. Walker
    • , Robin M. Warren
    • , Yanlin Zhao
    • , Matteo Zignol
    • , Marco Schito
    • , Jennifer Gardy
    • , Daniela M. Cirillo
    • , Stefan Niemann
    • , Inaki Comas
    •  & Annelies Van Rie
  • Analysis |

    CRISPR–Cas systems in bacteria and archaea have multifaceted evolutionary relationships with mobile genetic elements (MGEs), including viruses, plasmids and transposons. CRISPR–Cas systems or their components have also been recruited by MGEs on many independent occasions. In this Analysis article, Koonin and colleagues investigate and substantially expand the range of CRISPR–Cas components carried by MGEs.

    • Guilhem Faure
    • , Sergey A. Shmakov
    • , Winston X. Yan
    • , David R. Cheng
    • , David A. Scott
    • , Joseph E. Peters
    • , Kira S. Makarova
    •  & Eugene V. Koonin
  • Review Article |

    In this Review, Reyes-Lamothe and Sherratt describe the contributions of chromosome structure and nucleoid folding to cell cycle regulation, detail the cellular processes involved in the initiation of DNA replication and DNA segregation and explore how those processes are linked to cell growth and cell division.

    • Rodrigo Reyes-Lamothe
    •  & David J. Sherratt
  • Review Article |

    In this Review, Mitchell and Silhavy explore the cellular envelope stress response pathways and discuss what occurs when these pathways are aberrantly activated. They also discuss how recent insights into stress response activation have highlighted the extreme toxicity of unfolded outer membrane proteins.

    • Angela M. Mitchell
    •  & Thomas J. Silhavy
  • Review Article |

    Lipopolysaccharide is a key component of the Gram-negative cell envelope and functions, for example, as a permeability barrier or determinant of host immune responses. In this Review, Simpson and Trent guide us through lipopolysaccharide biogenesis and modifications and their functional and therapeutic implications.

    • Brent W. Simpson
    •  & M. Stephen Trent
  • Perspective |

    The origin of viruses is an unsolved, controversial question. In this Opinion article, Krupovic, Dolja and Koonin propose a new scenario for the origin of viruses based on primordial, selfish replicators acquiring structural proteins from cells, enabling them to form virions.

    • Mart Krupovic
    • , Valerian V. Dolja
    •  & Eugene V. Koonin

News & Comment

  • Research Highlight |

    A recent study reports that Cas13 induces a state of dormancy in bacteria, which inhibits viral replication and the rise of CRISPR-resistant phages.

    • Ashley York
  • Research Highlight |

    This study shows that bacteria can maintain efficient chemotaxis in the presence of obstacles by reducing their tumbling frequency.

    • Ursula Hofer
  • Genome Watch |

    This month’s Genome Watch highlights the use of genome-centric approaches to further our understanding of the human gut microbiome.

    • Tanja Woyke
  • Research Highlight |

    A recent study reports a force-independent form of flow-sensing in Pseudomonas aeruginosa.

    • Ashley York
  • Viewpoint |

    In this Viewpoint article, several experts discuss the microbial contributions to climate change and consider the effects of global warming, extreme weather and other consequences of climate change on microbial communities in the ocean and soil, host–microbiota interactions and the global burden of infectious diseases and ecosystem processes, and they explore open questions and research needs.

    • David A. Hutchins
    • , Janet K. Jansson
    • , Justin V. Remais
    • , Virginia I. Rich
    • , Brajesh K. Singh
    •  & Pankaj Trivedi
  • Comment |

    Global change microbiology is a rapidly growing research field on microbial responses to global warming, overuse and pollution and on feedback mechanisms and functions that affect Earth’s element cycles and planetary health. In this Comment, Antje Boetius explores how this field could provide essential knowledge and sustainable solutions to the problems driven by global change.

    • Antje Boetius


Gut Microbiota

Brain light / Alamy Stock Photo

Gut Microbiota

This collection combines published Research articles and Reviews from several Nature journals highlighting recent advances in our understanding of the role of the gut microbiota in health and disease, and the tools for studying these complex communities.

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