Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The RSK proteins are downstream effectors of the Ras–MAPK signalling cascade. Significant advances in RSK and Ras–MAPK signal transduction expand the current models of RSK-mediated signalling and highlight important functions for RSK proteins in cell survival, growth, proliferation and migration.
Ataxia-telangiectasia (A-T) was first described over 80 years ago. Since the discovery of the A-T mutated (ATM) protein, which is defective in A-T, rapid progress has been made regarding how ATM functions together with many other proteins to protect against genome instability.
Gene regulatory networks control many cellular processes such as cell cycle, cell differentiation, metabolism and signal transduction. Computational methods, both for supporting the development of network models and for the analysis of their functionality, have already proved to be a valuable research tool.
Phagosome maturation is the process by which a particle-containing phagosome 'matures' through a series of increasingly acidic membrane-bound structures, becoming an acidic phagolysosome before fusing with lysosomes. The identification of a pathway for apoptotic cell-containing phagosomes reveals parallels and differences with receptor-mediated endocytosis.
For more than a century, scientists have observed cells internalized inside other cells. These cell-in-cell structures often consist of viable rather than apoptotic cells, and can form by the invasion of one cell into another, rather than by engulfment. This review will address how cell-in-cell structures might form and what physiological roles they might have.
MYCis a potent oncogene that functions as a transcription factor. Extensive research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. But does MYC also have transcription-independent roles?
The 'histone code' hypothesis has inspired rapid advances throughout chromatin biology, and has recently been tapped for its relevance to non-histone proteins. What is the evidence that supports the existence of a protein code? And can this code be used to predict downstream events?