Volume 8 Issue 11, November 2007

From The Editors

Research Highlights

Reviews

  • Review Article |

    Recent studies of human genetic syndromes and transgenic mouse models with vascular pathology have exposed a crucial function of extracellular control in the regulation of TGFβ bioavailability in the vascular system. This Review discusses such regulation and the implications of defects in this process with regards to human health.

    • Peter ten Dijke
    •  & Helen M. Arthur
  • Review Article |

    Mitochondria constantly fuse and divide, are actively transported to specific subcellular localizations and have dynamic structures. Mitochondrial dynamics is important for the functional state of mitochondria, and defects can manifest in mammalian development, apoptosis and neurodegenerative disease.

    • Scott A. Detmer
    •  & David C. Chan
  • Review Article |

    Cilia — tiny hair-like organelles attached to the cell surface — are located on most polarized cells and have been adapted as versatile tools for various cellular functions. Several molecular mechanisms affecting the structure and function of distinct cilia types are associated with cilia-related disorders.

    • Manfred Fliegauf
    • , Thomas Benzing
    •  & Heymut Omran
  • Review Article |

    The successful completion of mitosis requires that late mitotic events occur in a strict sequence. This is regulated, at least in part, by the order in which different cyclin-dependent kinase substrates are dephosphorylated and in which anaphase-promoting complex substrates are degraded.

    • Matt Sullivan
    •  & David O. Morgan
  • Review Article |

    The vacuolar ATPases are proton pumps that have a central role in maintaining the pH of intracellular compartments and in proton transport across the plasma membrane. Their activity is controlled at many different levels and, increasingly, their dysregulation is being linked to specific diseases.

    • Michael Forgac

Perspectives