Volume 8 Issue 10, October 2007

From The Editors

Research Highlights


  • Review Article |

    Different classes of RNA molecules are synthesized in the eukaryotic nucleus and are exported through nuclear pore complexes to the cytoplasm by mobile export receptors. Small RNAs follow relatively simple export routes, whereas large RNAs assemble into complex ribonucleoproteins and require specific adaptor proteins.

    • Alwin Köhler
    •  & Ed Hurt
  • Review Article |

    Maintaining the balance between ATP production and consumption is essential for cell survival. AMP-activated protein kinase (AMPK) is an energy sensor that, when energy levels are low, stimulates catabolism to produce ATP and inhibits biosynthesis and proliferation to conserve ATP.

    • D. Grahame Hardie
  • Review Article |

    Recent studies on melanosome formation have provided insights into novel aspects of endosomal sorting that are involved in cell physiology, organelle biogenesis and amyloid formation. Genetic disorders that affect the formation of melanosomes and other lysosome-related organelles are revealing the molecular machinery that controls specialized sorting events.

    • Graça Raposo
    •  & Michael S. Marks
  • Review Article |

    The chromosomal passenger complex (CPC) orchestrates mitosis and meiosis at several different levels to ensure the accurate distribution of the genetic material to the daughter cells. Its functions range from the regulation of kinetochore–microtubule attachments to sister chromatid cohesion and cytokinesis.

    • Sandrine Ruchaud
    • , Mar Carmena
    •  & William C. Earnshaw
  • Review Article |

    The replication of telomeres poses unique problems, which the cell solves through specific mechanisms that coordinate the synthesis of the leading and lagging strands at telomeres. These mechanisms integrate the conventional replication machinery, telomere maintenance systems, DNA response pathways and chromosomal organization.

    • Eric Gilson
    •  & Vincent Géli



  • Essay |

    Cell monolayers have serious limitations for cell biological investigations and for cell-based assays in drug screening and toxicity studies. However, the establishment of three-dimensional cultures as a mainstream approach requires the development of reliable protocols, new cell lines and suitable imaging techniques.

    • Francesco Pampaloni
    • , Emmanuel G. Reynaud
    •  & Ernst H. K. Stelzer