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Volume 23 Issue 9, September 2022

‘Nuclei feeling the squeeze’, inspired by the Review on p583.

Cover design: Neil Smith

Comment

  • Kempson and colleagues suggest that existing imaging assays do not quantitatively represent double-strand DNA breaks, and urge the development of more accurate assays.

    • Jake Atkinson
    • Eva Bezak
    • Ivan Kempson
    Comment

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Research Highlights

  • Sladitschek-Martens show that reduced activity of key cellular mechanosensors, transcription co-activators YAP/TAZ, is an important driver of ageing of stromal and contractile cells, leading to cell senescence.

    • Paulina Strzyz
    Research Highlight
  • Kirova et al. demonstrate that reactive oxygen species signals are integrated into cell cycle control through a direct interaction with cyclin-dependent kinase 2.

    • Lisa Heinke
    Research Highlight
  • Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases, in early mammalian development.

    • Paulina Strzyz
    Research Highlight
  • Olivia Rissland recounts the findings of a paper that was seminal to our understanding of mRNA decay.

    • Olivia S. Rissland
    Journal Club
  • Hiroshide Saito discusses two seminal papers that provided foundational evidence for the hypothesis that RNA with both genetic information and catalytic activity had an essential role in the origin of life.

    • Hirohide Saito
    Journal Club
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Reviews

  • Nuclei are subject to various deformations, being pulled, pushed, squeezed and stretched by a plethora of intracellular and extracellular forces. Recent work is unravelling how nuclei sense and respond to these deformations, including with changes in genome organization and function, cell signalling, and cell mechanics.

    • Yohalie Kalukula
    • Andrew D. Stephens
    • Sylvain Gabriele
    Review Article
  • Nuclear transcription of a wide variety of RNA species is conducted mainly by three RNA polymerases, which are large and dynamic protein complexes. Recent structural studies have provided important insights into the activities at different transcription stages and the commonalities and differences between these transcription machineries.

    • Mathias Girbig
    • Agata D. Misiaszek
    • Christoph W. Müller
    Review Article
  • Histone H3 Lys9 (H3K9)-methylated heterochromatin ensures transcriptional silencing of repetitive elements and genes, and its deregulation leads to impaired cell and tissue identity, premature aging and cancer. Recent studies in mammals clarified the roles H3K9-specific histone methyltransferases in ensuring transcriptional homeostasis during tissue differentiation.

    • Jan Padeken
    • Stephen P. Methot
    • Susan M. Gasser
    Review Article
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