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Volume 23 Issue 5, May 2022

‘Extracellular vesicle communication’, inspired by the Expert Recommendation on p369.

Cover design: Vicky Summersby

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Research Highlights

  • Arnold et al. document an alternative tricarboxylic acid cycle that takes place between the mitochondria and the cytosol and that can be adopted in specific cell states.

    • Paulina Strzyz
    Research Highlight
  • The transcription factor c-Maf is required for the specification of liver sinusoids and for the maintenance of a specialized sinusoidal network necessary for sustaining hepatocyte function.

    • Kim Baumann
    Research Highlight
  • Ting and Lee describe how the trypanosome base J ‘inspired’ the discovery of the mechanism of active DNA demethylation.

    • Angela H. Ting
    • Byron H. Lee
    Journal Club
  • Transposons and their host genomes are entangled in an evolutionary arms race, recounts Tuğçe Aktaş.

    • Tuğçe Aktaş
    Journal Club
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Reviews

  • The majority of macromolecules are transported across the nuclear membrane by the Karyopherin-β (Kap) proteins, comprising importins, exportins and biportins. Unravelling mechanisms and regulation of Kap–cargo interactions is essential for understanding nuclear export and import of proteins and RNA and how this traffic impacts their physiological functions.

    • Casey E. Wing
    • Ho Yee Joyce Fung
    • Yuh Min Chook
    Review Article
  • Lysine acetyltransferases and lysine deacetylases regulate gene expression and protein function by controlling acetylation and deacetylation of histones and diverse non-histone proteins. The activity of lysine acetyltransferases and lysine deacetylases is regulated by cellular metabolic states, offering the potential for therapeutic modulation through dietary and pharmacological interventions.

    • Maria Shvedunova
    • Asifa Akhtar
    Review Article
  • E3 ubiquitin ligases ensure the precise spatiotemporal control of key molecules during important cellular processes. This Review discusses the crucial roles of E3 ligases during early mammalian development and their roles in human disease, and considers how new methods to manipulate the ubiquitin regulatory machinery — for example, the development of molecular glues and PROTACs — might facilitate clinical therapy.

    • David A. Cruz Walma
    • Zhuoyao Chen
    • Kenneth M. Yamada
    Review Article
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Expert Recommendation

  • Extracellular vesicles (EVs) mediate cell–cell communication in physiology and pathology but many questions remain about the mechanisms governing their delivery to recipient cells. This Expert Recommendation article highlights areas of progress and challenges in establishing the importance of EV-mediated communication in vivo.

    • Guillaume van Niel
    • David R. F. Carter
    • Pieter Vader
    Expert Recommendation
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