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Volume 19 Issue 6, June 2018

‘An autophagy journey’ inspired by the Review on p349

Cover design: Vicky Summersby

Comment

  • The commonly used budding yeast strain W303 carries a mutant RAD5 gene (rad5-535), but numerous laboratories use a strain corrected for the mutation. This has resulted in different phenotypes of W303 cells in similar experiments. Here, we aim to raise awareness of the issue to ensure data reproducibility and interpretation.

    • Menattallah Elserafy
    • Sherif F. El-Khamisy
    Comment

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Research Highlights

  • The lysosomal degradation of protein aggregates declines with ageing in mammalian neural stem cells, reducing their capacity to transition from a quiescent to an active state.

    • Paulina Strzyz
    Research Highlight
  • Shieldin is a newly characterized protein complex that functions downstream of 53BP1 in promoting NHEJ

    • Eytan Zlotorynski
    Research Highlight
  • The microRNA-induced silencing complex undergoes phase separation, which promotes the sequestration and deadenylation of target mRNAs.

    • Anne Mirabella
    Research Highlight
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Reviews

  • Autophagy is a process of cellular self-consumption that promotes cell survival in response to stress. Various human pathologies, including cancer, neurodegeneration and inflammation, have been associated with aberrant autophagy, and recent studies of the mechanisms and regulation of autophagy in higher eukaryotes have suggested new therapeutic possibilities.

    • Ivan Dikic
    • Zvulun Elazar
    Review Article
  • The selective degradation of cellular components via chaperone-mediated autophagy (CMA) functions to regulate a wide range of cellular processes, from metabolism to DNA repair and cellular reprogramming. Recent in vivo studies have enabled to dissect key roles of CMA in ageing and ageing-associated disorders such as cancer and neurodegeneration.

    • Susmita Kaushik
    • Ana Maria Cuervo
    Review Article
  • Cytoplasmic dynein is a minus-end-directed microtubule-based motor that transports a wide range of cargoes, including organelles, RNAs, protein complexes and viruses. How a single motor can interact with and traffic such different cargoes has been unclear. Recent studies indicate how adaptor proteins, which can both activate dynein and link it to cargo, play an important role in this process.

    • Samara L. Reck-Peterson
    • William B. Redwine
    • Andrew P. Carter
    Review Article
  • Single-cell technologies are transforming our understanding of pre-implantation and early post-implantation development and of in vitro pluripotency. Specifically, single-cell transcriptomics and imaging and the accompanying bioinformatics methods have enabled precision interrogation of cell fate choices and cell lineage diversification, which occur at the level of the individual cell.

    • Blanca Pijuan-Sala
    • Carolina Guibentif
    • Berthold Göttgens
    Review Article
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