Volume 19 Issue 3, March 2018

Volume 19 Issue 3

'The power of linking' by Vicky Summersby, inspired by the Review on p192.

Comment

  • Comment |

    Images are an integral part of reporting scientific data and conveying concepts in science. Janke and Chabrier argue for the importance of hand drawing — the original form of representation in science — as a complementary medium to photographs and schematics used in science publications today.

    • Renaud Chabrier
    •  & Carsten Janke

Research Highlights

Reviews

  • Review Article |

    Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity.

    • Julia D. Ransohoff
    • , Yuning Wei
    •  & Paul A. Khavari
  • Review Article |

    Structures in 5′ untranslated regions of eukaryotic mRNAs contribute to gene regulation by controlling cap-dependent and cap-independent translation initiation through diverse mechanisms. New structure probing technologies coupled with techniques such as compensatory mutagenesis will likely identify new structured RNA elements and help elucidate their function.

    • Kathrin Leppek
    • , Rhiju Das
    •  & Maria Barna
  • Review Article |

    Sphingolipids are a major class of lipids, comprising various species with diverse functions. In addition to being structural elements of membranes, many sphingolipids are bioactive and regulate a myriad of cellular processes. Recent advances have shed new light on the complexity of sphingolipid metabolism and their various roles in physiology and disease.

    • Yusuf A. Hannun
    •  & Lina M. Obeid
  • Review Article |

    Linker histones bind to nucleosomes and have been traditionally perceived as structural units of chromatin. Recent advances indicate that these histones have an active role in the control of chromatin architecture and function, participating in the regulation of gene expression, DNA replication and DNA repair.

    • Dmitry V. Fyodorov
    • , Bing-Rui Zhou
    • , Arthur I. Skoultchi
    •  & Yawen Bai