Volume 19 Issue 1, January 2018

Volume 19 Issue 1

'Making sense of translation' by Vicky Summersby, inspired by the Review on p20 and the series on translation and protein quality control.

Research Highlights

  • Research Highlight |

    The entire skin of a young patient with junctional epidermolysis bullosa was successfuly regenerated using a combination of ex vivo gene therapy and stem-cell replacement therapy, which is a major achievement in the translation of stem cell-based therapies to the clinic.

    • Kim Baumann
  • Research Highlight |

    The production of circular RNAs is enhanced when canonical splicing of parent genes or transcription termination at upstream genes is reduced.

    • Eytan Zlotorynski

Reviews

  • Review Article |

    Heat shock transcription factors (HSFs) regulate heat shock proteins in conditions of thermal stress, but they also control gene expression in other stress conditions, as well as in other contexts, including the regulation of cell proliferation and energy metabolism. HSFs are misregulated in various diseases, such as cancer and neurodegeneration, which underlines their important physiological roles.

    • Rocio Gomez-Pastor
    • , Eileen T. Burchfiel
    •  & Dennis J. Thiele
  • Review Article |

    Research over the past few decades has elucidated the biochemical mechanisms underlying insulin receptor signalling. Recent insights into the complexity of its temporal and tissue-specific regulation, which involves various combinations of signalling modules in different cell types, are shedding light on the pleiotropic effects of insulin action and the pathogenesis of insulin resistance.

    • Rebecca A. Haeusler
    • , Timothy E. McGraw
    •  & Domenico Accili
  • Review Article |

    tRNAs exist as diverse species, including sequence isoforms and nuclease-generated fragments, which are further functionally diversified by base modifications and various protein interactions. Perhaps unsurprisingly, tRNAs are now being implicated in various cellular processes beyond protein synthesis per se, including in stress responses, proliferation, cell fate determination and tumorigenesis.

    • Paul Schimmel
  • Review Article |

    Ubiquitylation is a post-translational modification that modulates protein stability and regulates various cellular signalling pathways and cellular processes, including cell differentiation, proliferation and migration. Recent insights highlight its crucial role in development and how its deregulation is associated with several diseases.

    • Michael Rape