Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Two papers report a new mechanism of controlling alternative splicing through phase separation-mediated formation of higher-order assemblies of splicing factors.
Following irradiation, adipocytes derived from a specified subset of leptin receptor-positive cells in the bone marrow become a major source of stem cell factor for haematopoietic regeneration.
Patterns of histone H3 Lys27 trimethylation are maternally inherited in both fly and mammalian embryos, and control gene expression during early development.
Sirtuin 1 deacetylates polyadenylate-binding protein 1 (PABP1), thereby suppressing nuclear export of polyadenylated mRNAs and translation to preserve energy under stress.
A new imaging technique (ChromEMT) enables the visualization of the local polymer structure and global 3D organization of chromatin in the nucleus of intact interphase and mitotic human cells.
Motile and non-motile primary cilia are nearly ubiquitous cellular organelles. Dysfunction of cilia is being found to cause increasing numbers of diseases that are known as ciliopathies. The characterization of ciliopathy-associated proteins and phenotypes is increasing our understanding of how cilia are formed and compartmentalized and how they function to maintain human health.
The presence of nucleosomes and their substructures affects local chromatin structure and function. Thus, nucleosome occupancy, their exact positioning and composition need to be dynamically regulated. Advances in genomic technologies have improved our understanding of nucleosome dynamics in various cellular processes, most notably DNA replication and transcription.
Covalent DNA–protein crosslinks (DPCs) are induced by various compounds, which include widely used anticancer drugs, and are highly cytotoxic. Recent studies have revealed the mechanisms and the regulation of DPC repair pathways and suggest that components of these pathways can serve as targets for anticancer therapies.
A comprehensive analysis of small open reading frames (smORFs) in flies, mice and humans supports their classification into different functional groups, from inert DNA sequences to transcribed and translated smORFs that have various activities. The different smORF classes could represent steps in gene, peptide and protein evolution.
