Volume 18 Issue 9, September 2017

Volume 18 Issue 9

'Mighty smORFs in action' by Vicky Summersby, inspired by the Analysis on p575.

Research Highlights

  • Research Highlight |

    Two papers report a new mechanism of controlling alternative splicing through phase separation-mediated formation of higher-order assemblies of splicing factors.

    • Eytan Zlotorynski
  • Research Highlight |

    Following irradiation, adipocytes derived from a specified subset of leptin receptor-positive cells in the bone marrow become a major source of stem cell factor for haematopoietic regeneration.

    • Kim Baumann
  • Research Highlight |

    Sirtuin 1 deacetylates polyadenylate-binding protein 1 (PABP1), thereby suppressing nuclear export of polyadenylated mRNAs and translation to preserve energy under stress.

    • Paulina Strzyz
  • Research Highlight |

    Patterns of histone H3 Lys27 trimethylation are maternally inherited in both fly and mammalian embryos, and control gene expression during early development.

    • Paulina Strzyz
  • Research Highlight |

    The lincRNA Neat1 is a p53 target gene that can suppress the initiation of pancreatic cancer.

    • Eytan Zlotorynski
  • Research Highlight |

    A new imaging technique (ChromEMT) enables the visualization of the local polymer structure and global 3D organization of chromatin in the nucleus of intact interphase and mitotic human cells.

    • Kim Baumann

Reviews

  • Review Article |

    Motile and non-motile primary cilia are nearly ubiquitous cellular organelles. Dysfunction of cilia is being found to cause increasing numbers of diseases that are known as ciliopathies. The characterization of ciliopathy-associated proteins and phenotypes is increasing our understanding of how cilia are formed and compartmentalized and how they function to maintain human health.

    • Jeremy F. Reiter
    •  & Michel R. Leroux
  • Review Article |

    The presence of nucleosomes and their substructures affects local chromatin structure and function. Thus, nucleosome occupancy, their exact positioning and composition need to be dynamically regulated. Advances in genomic technologies have improved our understanding of nucleosome dynamics in various cellular processes, most notably DNA replication and transcription.

    • William K. M. Lai
    •  & B. Franklin Pugh
  • Review Article |

    Covalent DNA–protein crosslinks (DPCs) are induced by various compounds, which include widely used anticancer drugs, and are highly cytotoxic. Recent studies have revealed the mechanisms and the regulation of DPC repair pathways and suggest that components of these pathways can serve as targets for anticancer therapies.

    • Julian Stingele
    • , Roberto Bellelli
    •  & Simon J. Boulton

    Series:

Analysis

  • Analysis |

    A comprehensive analysis of small open reading frames (smORFs) in flies, mice and humans supports their classification into different functional groups, from inert DNA sequences to transcribed and translated smORFs that have various activities. The different smORF classes could represent steps in gene, peptide and protein evolution.

    • Juan-Pablo Couso
    •  & Pedro Patraquim