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Volume 18 Issue 6, June 2017

'Dynamic rafts' by Vicky Summersby, inspired by the Review on p361.

Comment

  • Novoa, Mason and Mattick propose to use phage display technology and direct sequencing through nanopores to facilitate systematic interrogation of RNA modifications.

    • Eva Maria Novoa
    • Christopher E. Mason
    • John S. Mattick
    Comment

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Research Highlight

  • Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines.

    • Kim Baumann
    Research Highlight
  • The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death.

    • Paulina Strzyz
    Research Highlight
  • An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay.

    • Eytan Zlotorynski
    Research Highlight
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Journal Club

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Research Highlight

  • Expansion of polyglutamine tracts in proteins interferes with the process of autophagy and may contribute to the pathology of neurodegenerative diseases.

    • Paulina Strzyz
    Research Highlight
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Review Article

  • The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis. Recent progress has shed light on the interactions of HSP90 with its clients and co-chaperones, and on their functional implications. This opens up new avenues for the development of drugs that target HSP90, which could be valuable for the treatment of cancers and protein-misfolding diseases.

    • Florian H. Schopf
    • Maximilian M. Biebl
    • Johannes Buchner
    Review Article
  • Lipid rafts are relatively ordered membrane domains that are enriched in cholesterol and saturated lipids, and selectively recruit other lipids and proteins. They are dynamic and heterogeneous in composition and are thus challenging to visualizein vivo. New technologies are providing novel insights into the formation, organization and functions of these membrane domains.

    • Erdinc Sezgin
    • Ilya Levental
    • Christian Eggeling
    Review Article
  • Planar cell polarity — the asymmetric distribution of proteins in the plane of a cell sheet — dictates the orientation of various subcellular structures and drives collective cell rearrangements. Better understanding of this conserved axis of polarity can shed light on the mechanisms of morphogenetic processes and explain the underlying causes of human birth defects.

    • Mitchell T. Butler
    • John B. Wallingford
    Review Article
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Opinion

  • In animal cells, actin is dynamically distributed between multiple coexisting arrays. Carlier and Shekhar propose that a global treadmilling process — whereby the various actin networks grow and shrink depending on the local activity of actin regulators — establishes a steady-state concentration of actin monomers that supports this homeostatic actin turnover.

    • Marie-France Carlier
    • Shashank Shekhar
    Opinion
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