Volume 18 Issue 4, April 2017

Volume 18 Issue 4

'Sowing the seeds of specificity' by Vicky Summersby, inspired by the Review on p215.

Research Highlights


  • Review Article |

    Insights into eukaryotic, bacterial and archaeal RNA-based regulatory systems, including microRNAs, small interfering RNAs, clustered regularly interspaced short palindromic repeats (CRISPR) RNA and small RNAs that are dependent on the RNA chaperone protein Hfq, have revealed that they achieve specificity using similar strategies. Specifically, the presentation of short 'seed sequences' within a ribonucleoprotein complex facilitates the search for and recognition of targets.

    • Stanislaw A. Gorski
    • , Jörg Vogel
    •  & Jennifer A. Doudna


  • Review Article |

    The nuclear envelope is more than a static barrier between the nuclear and cytoplasmic compartments. It is very dynamic and undergoes extensive remodelling in response to mechanical challenges as well as during cell division, growth and differentiation.

    • Rosemarie Ungricht
    •  & Ulrike Kutay
  • Review Article |

    Bromodomains (BRDs) are domains found in diverse proteins that recognize acetylated Lys residues, primarily on histones. Hence, BRD-containing proteins serve as readers of protein acetylation and engage in the regulation of gene expression. Recent studies have provided new insights into the physiological roles of BRD-containing proteins and their deregulation in cancer.

    • Takao Fujisawa
    •  & Panagis Filippakopoulos
  • Review Article |

    The carboxy-terminal domain (CTD) of RNA polymerase II is a repetitive and unstructured domain that is dynamically modified by post-translational modifications, which collectively constitute the 'CTD code'. Recent studies have revealed how CTD function is also promoted by phase separation in the presence of other low-complexity domains.

    • Kevin M. Harlen
    •  & L. Stirling Churchman