Volume 18 Issue 1, January 2017

Volume 18 Issue 1

'Modifying wintery RNA' by Vicky Summersby, inspired by the Review on p31.

Research Highlights

Reviews

  • Review Article |

    New observations of ESCRT-mediated reverse-topology membrane scission are building towards a structural and biophysical explanation of the mechanism involved.

    • Johannes Schöneberg
    • , Il-Hyung Lee
    • , Janet H. Iwasa
    •  & James H. Hurley
  • Review Article |

    Alternative polyadenylation (APA) generates mRNAs with varying 3′ termini. It is regulated by variation in the concentration of cleavage and polyadenylation factors and by RNA-binding proteins, as well as by splicing and transcription. APA is important for cell proliferation and differentiation owing to its roles in mRNA metabolism and protein diversification.

    • Bin Tian
    •  & James L. Manley
  • Review Article |

    Reversible mRNA methylation is an emerging mode of eukaryotic post-transcriptional gene regulation. N6-methyladenosine (m6A) affects mRNA processing, translation and decay during cell differentiation, embryonic development and stress responses. Other mRNA modifications — N1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine — together with m6A code a new layer of information that controls protein synthesis.

    • Boxuan Simen Zhao
    • , Ian A. Roundtree
    •  & Chuan He
  • Review Article |

    Contact inhibition of locomotion (CIL) involves collisions with other cells during cell migration that typically induce cessation of movement or a change of migratory direction. A molecular description of CIL and details of its involvement in various cellular processes are emerging, demonstrating that CIL is a highly heterogeneous response with important functions in vivo.

    • Brian Stramer
    •  & Roberto Mayor
  • Review Article |

    Human pluripotent stem cells constitute a unique system to study the earliest stages of human embryonic haematopoiesis and the origins of human blood cell diseases, and they are an invaluable tool for the generation of haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

    • Andrea Ditadi
    • , Christopher M. Sturgeon
    •  & Gordon Keller