Volume 17 Issue 9, September 2016

Volume 17 Issue 9

'Barriers to communication' by Vicky Summersby, inspired by the Review on p564.

Research Highlights


  • Review Article |

    Selective autophagy pathways engage selective autophagy receptors (SARs) that identify and bind to cellular cargoes (proteins or organelles) destined for degradation. Recent yeast studies have provided insights into the regulation and mechanisms underlying SAR function. As these mechanisms are conserved from yeast to mammals, it is now possible to formulate general principles of how selectivity during autophagy is achieved.

    • Jean-Claude Farré
    •  & Suresh Subramani
  • Review Article |

    Encounters and conflicts between the transcription and replication machineries are common and represent a major intrinsic source of genome instability. Recent data shed new light on the biological relevance of transcription–replication conflicts and the factors and mechanisms involved in either preventing or resolving them.

    • Tatiana García-Muse
    •  & Andrés Aguilera


  • Review Article |

    Tight junctions are barriers between epithelial and endothelial cells that regulate the diffusion of molecules across tissues; they also contribute to cell polarity and serve as signalling platforms. Recent findings have broadened our understanding of tight junction organization, assembly and function.

    • Ceniz Zihni
    • , Clare Mills
    • , Karl Matter
    •  & Maria S. Balda


  • Analysis |

    Analysis of the available human small ubiquitin-like modifier (SUMO) proteomics data provided evidence for the sumoylation of thousands of proteins and residues, and clustered the sumoylated proteins into functional networks. Sumoylation is a frequent modification, occurring mostly on nuclear proteins, with functions including transcription, mRNA processing and the DNA-damage response.

    • Ivo A. Hendriks
    •  & Alfred C. O. Vertegaal