Volume 17 Issue 6, June 2016

Volume 17 Issue 6

'Fixing DNA damage' by Nicola Hawes, inspired by this Focus issue.

Research Highlights

Comment

  • Comment |

    Tomas Lindahl presents a case for keeping DNA in the organic solvent glycol, in which it keeps its activity and is better protected from contamination and, potentially, radiation.

    • Tomas Lindahl

Reviews

  • Review Article |

    Ribonucleotides are incorporated into DNA by various mechanisms, including by DNA polymerases during replication. Such ribonucleotides may have physiological functions, but their presence is typically associated with diverse structural aberrations and interferes with fundamental processes, including DNA replication, repair and transcription. Thus, efficient mechanisms of ribonucleotide removal are key to maintaining genomic integrity and functionality.

    • Jessica S. Williams
    • , Scott A. Lujan
    •  & Thomas A. Kunkel
  • Review Article |

    Double-strand break (DSB) repair at telomeres — the ends of linear chromosomes — can cause chromosome end fusions and genomic instability, which drives tumorigenesis. As several mechanisms protect mammalian telomeres from the DNA damage response, telomeres have emerged as a system to uncover key steps in DSB repair.

    • Eros Lazzerini-Denchi
    •  & Agnel Sfeir
  • Review Article |

    Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs), and crosstalk between these modifications, underlies cellular responses to DNA double-strand breaks (DSBs). Important insights have been gained into the mechanisms by which ubiquitin and UBLs regulate protein interactions at DSB sites to enable accurate repair in mammalian cells, thereby protecting genome integrity.

    • Petra Schwertman
    • , Simon Bekker-Jensen
    •  & Niels Mailand