Volume 17 Issue 3, March 2016

Volume 17 Issue 3

'Fates and translational potential of pluripotent stem cells' by Vicky Summersby, inspired by this Focus issue.

Research Highlights

Foreword

Reviews

  • Review Article |

    The ectopic expression of a defined set of transcription factors can experimentally reprogramme somatic cells into other cell types, including pluripotent cells. This method enables exploration of the molecular characteristics of pluripotency, cell specification, differentiation and cell fate stability, as well as their transcriptional and epigenetic regulation.

    • Zachary D. Smith
    • , Camille Sindhu
    •  & Alexander Meissner
  • Review Article |

    The use of cultured human pluripotent stem cells (PSCs) to model human diseases has revolutionized the ways in which we study monogenic, multigenic and epigenetic disorders, by overcoming some of the limitations of animal models. PSC-based disease models are generated using various strategies and can be used for the discovery of new drugs and therapies.

    • Yishai Avior
    • , Ido Sagi
    •  & Nissim Benvenisty

Perspectives

    Timeline

  • Timeline |

    This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how, since then, research has focused on understanding the mechanisms underlying iPSC generation and on translating such advances to the clinic.

    • Kazutoshi Takahashi
    •  & Shinya Yamanaka
  • Science and society

  • Science and Society |

    Advances in the derivation of pluripotent stem cells (PSCs) and their differentiation to specific cell types could have diverse clinical applications. Trounson and DeWitt provide an overview of the progress in using embryonic stem cell and induced PSC derivatives for disease treatment and discuss the potential and limitations of such approaches.

    • Alan Trounson
    •  & Natalie D. DeWitt