Volume 17 Issue 2, February 2016

Volume 17 Issue 2

'Making contacts' by Vicky Summersby, inspired by the Review on p69.

Research Highlights

Reviews

  • Review Article |

    Endoplasmic reticulum (ER) is typically associated with protein biogenesis. However, recent studies suggest that it additionally synchronizes and regulates a plethora of intracellular events owing to its ability to form tight membrane associations, so-called membrane contact sites (MCSs), with other organelles.

    • Melissa J. Phillips
    •  & Gia K. Voeltz
  • Review Article |

    ADAR enzymes convert adenosine to inosine (A-to-I editing) at numerous double-stranded Alu repeats in human transcripts, thereby affecting many cellular processes. Primary microRNAs (miRNAs) are also edited, and ADAR1 directly interacts with Dicer, resulting in the modulation of miRNA expression and activity and of downstream gene expression programmes during embryogenesis.

    • Kazuko Nishikura
  • Review Article |

    Collective cell migration has a crucial role during morphogenesis, wound healing and tissue renewal, and it is involved in cancer spreading. Recent studies highlight the importance of intercellular communication in this process: migration is driven by leader cells at the front, and follower cells communicate between them and with the leaders to improve the efficiency of collective movement.

    • Roberto Mayor
    •  & Sandrine Etienne-Manneville

Perspectives

    Opinion

  • Opinion |

    Members of the major facilitator superfamily are highly conserved transmembrane proteins that transport various small molecules, including nutrients, drugs, signalling molecules and waste products, across the plasma membrane. A novel model of their functional cycle provides insights into how these important transporters operate on the molecular level.

    • Esben M. Quistgaard
    • , Christian Löw
    • , Fatma Guettou
    •  & Pär Nordlund