Volume 16 Issue 8, August 2015

Volume 16 Issue 8

‘Shaping cells’ by Vicky Summersby, inspired by the Review on p486.

Research Highlights


  • Progress |

    Recent findings revealed that DNA–protein crosslinks (DPCs) in yeast and Xenopus laevis are repaired by a dedicated, protease-based DNA-repair pathway. Mutations in the putative human homologue of a DPC protease result in premature ageing and cancer predisposition.

    • Julian Stingele
    •  & Stefan Jentsch


  • Review Article |

    Autophagy serves to degrade proteins during starvation. Recent progress has illuminated how, during starvation and nutrient repletion, autophagy can mobilize diverse cellular energy and nutrient stores, such as lipids, carbohydrates and iron, to salvage key metabolites that sustain and facilitate core anabolic functions.

    • Jasvinder Kaur
    •  & Jayanta Debnath
  • Review Article |

    Aneuploidy, which results from chromosome mis-segregation, is a hallmark of cancer, but it can also inhibit tumorigenesis. Recent studies on the short- and long-term consequences of aneuploidy, which are caused by gene-specific effects and a stereotypic aneuploidy stress response, provide insights into this contradictory role in tumorigenesis.

    • Stefano Santaguida
    •  & Angelika Amon
  • Review Article |

    Actomyosin-mediated contractility generates mechanical stress in animal cells and underlies muscle contraction, cell migration, cell division and tissue morphogenesis. Insight into the mechanics of actomyosin arrays that lack sarcomeric organization has revealed novel modes of force transmission and shown that diverse mechanical behaviours can arise from common molecular components.

    • Michael Murrell
    • , Patrick W. Oakes
    • , Martin Lenz
    •  & Margaret L. Gardel
  • Review Article |

    Repressive histone Lys methyltransferases (KMTs) mediate gene silencing by methylating histone H3 Lys 9 (H3K9), H3K27 and H4K20. Progress has been made in our understanding of the biochemical and functional properties of KMTs, the mechanisms of their recruitment to chromatin and the interplay between them.

    • Chiara Mozzetta
    • , Ekaterina Boyarchuk
    • , Julien Pontis
    •  & Slimane Ait-Si-Ali