Volume 16 Issue 2, February 2015

Volume 16 Issue 2

'Making crystals' by Vicky Summersby, inspired by the Review on p69.

Research Highlights


  • Review Article |

    Considerable progress has been made in the past few years in our ability to visualize the structure of G protein-coupled receptors (GPCRs) and their signalling complexes. This is due to a series of technical improvements in areas such as protein engineering, lipidic cubic phase-based crystallization and microfocus synchrotron beamlines.

    • Eshan Ghosh
    • , Punita Kumari
    • , Deepika Jaiman
    •  & Arun K. Shukla
  • Review Article |

    The anaphase-promoting complex (also known as the cyclosome) is an E3 ubiquitin ligase that has a crucial function in the regulation of mitosis, particularly during anaphase and mitotic exit. Its activity is tightly controlled by several factors to ensure the timely degradation of key mitotic regulators and thus the proper progression of mitotic events.

    • Sushama Sivakumar
    •  & Gary J. Gorbsky
  • Review Article |

    The subcellular localization of mRNAs enables the spatial regulation of protein translation and generates functional and structural asymmetries in cells. New imaging (and other) techniques for tracking single-mRNA dynamics have unravelled mechanisms of mRNA movements and localization patterns in various cell types.

    • Adina R. Buxbaum
    • , Gal Haimovich
    •  & Robert H. Singer
  • Review Article |

    Retinoic acid regulates transcription by interacting with nuclear retinoic acid receptors, which bind to retinoic acid response elements near target genes. Recent studies have refined our knowledge of retinoic acid function in the limb, which serves as a paradigm for understanding how it regulates other developmental processes, such as somitogenesis, neuronal differentiation and organogenesis.

    • Thomas J. Cunningham
    •  & Gregg Duester