Volume 16 Issue 1, January 2015

Volume 16 Issue 1

'Disordered queues' by Vicky Summersby, inspired by the Review on p18.

Research Highlights

Reviews

  • Review Article |

    Lys and Arg methylation on non-histone proteins regulates various signalling pathways, and its crosstalk with other post-translational modifications and with histone methylation affects cellular processes such as transcription and DNA damage repair. Advances in proteomics now allow us to decode the methylproteome and elucidate its functions.

    • Kyle K. Biggar
    •  & Shawn S.-C. Li
  • Review Article |

    Intrinsically disordered proteins (IDPs) are key components of the cellular signalling machinery. Their flexible conformation enables them to interact with different partners and to participate in the assembly of signalling complexes and membrane-less organelles; this leads to different cellular outcomes. Post-translational modification of IDPs and alternative splicing add complexity to regulatory networks.

    • Peter E. Wright
    •  & H. Jane Dyson
  • Review Article |

    Post-translational modification of proteins by NEDD8 has been mainly characterized in terms of the cullin–RING E3 ligase family. However, recent studies have indicated that there might be non-cullin neddylation targets that require further verification.

    • Radoslav I. Enchev
    • , Brenda A. Schulman
    •  & Matthias Peter

Perspectives

    Opinion

  • Opinion |

    Faithful chromosome segregation during mitosis depends on the bi-oriented attachment of chromosomes to spindle microtubules through their kinetochores. The precise regulation of kinetochore–microtubule attachment that ensures error-free mitosis may be explained by homeostatic principles involving receptors, a core control network, effectors and feedback control.

    • Kristina M. Godek
    • , Lilian Kabeche
    •  & Duane A. Compton