Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Current research illustrates that various proteins, implicated in both physiological and pathological processes, can undergo phase separation to form liquid droplets.
DNA damage repair is in the spotlight this year — the Nobel Prize in Chemistry 2015 was awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar “for mechanistic studies of DNA repair”.
The ubiquitylation enzyme cullin 3 and its adaptor KBTBD8 mediate stem cell specification into neural crest by modulating the translation of a specific set of mRNAs.
Recent findings have demonstrated that Polycomb repressive complexes (PRCs) control gene expression through their co-recruitment to specific CpG island elements with transcription factors and non-coding RNAs. Moreover, they revealed that the interplay between PRC1 and PRC2 to achieve transcriptional repression is more intricate than was previously thought.
Ribosome profiling has the power to interrogate —in vivoand on a global scale — what is being translated, how this translation is regulated and where in the cell the translation of specific sets of proteins occurs.
Nonsense-mediated mRNA decay (NMD) degrades mRNAs with abnormally positioned translation termination codons. It is now becoming apparent that NMD targets mRNAs to enable mammalian cells to adjust their transcriptomes and their proteomes to changing physiological conditions and during diverse cellular processes.
Glucose from excess dietary carbohydrate is converted to fatty acids in the liver throughde novolipogenesis. Lipogenic genes have common features in their promoters and are coordinately regulated at the transcriptional level. Recent insights have been gained into the signalling pathways that regulate key transcription factors such as USFs, SREBP1C, LXRs and ChREBP.
The discovery of modular protein- and lipid-binding domains was a crucial turning point in our understanding of the logic and evolution of cell signalling mechanisms. The late, great Tony Pawson was instrumental in their discovery.
