Volume 16 Issue 11, November 2015

Volume 16 Issue 11

'RNA footprints' by Vicky Summersby, inspired by the Review on p651.

Research Highlights



  • Progress |

    Recent findings have demonstrated that Polycomb repressive complexes (PRCs) control gene expression through their co-recruitment to specific CpG island elements with transcription factors and non-coding RNAs. Moreover, they revealed that the interplay between PRC1 and PRC2 to achieve transcriptional repression is more intricate than was previously thought.

    • Neil P. Blackledge
    • , Nathan R. Rose
    •  & Robert J. Klose


  • Review Article |

    Nonsense-mediated mRNA decay (NMD) degrades mRNAs with abnormally positioned translation termination codons. It is now becoming apparent that NMD targets mRNAs to enable mammalian cells to adjust their transcriptomes and their proteomes to changing physiological conditions and during diverse cellular processes.

    • Søren Lykke-Andersen
    •  & Torben Heick Jensen
  • Review Article |

    Glucose from excess dietary carbohydrate is converted to fatty acids in the liver through de novo lipogenesis. Lipogenic genes have common features in their promoters and are coordinately regulated at the transcriptional level. Recent insights have been gained into the signalling pathways that regulate key transcription factors such as USFs, SREBP1C, LXRs and ChREBP.

    • Yuhui Wang
    • , Jose Viscarra
    • , Sun-Joong Kim
    •  & Hei Sook Sul