Volume 15 Issue 6, June 2014

Volume 15 Issue 6

'Matching pairs' by Neil Smith, inspired by the Review on p369.

Research Highlights

Reviews

  • Review Article |

    Homologous recombination is crucial for genome stability and for genetic exchange. Our knowledge of homology search, the step in this process that explores the genome for homologous sequences to enable recombination, has been increased by recent methodological advances. These insights can be integrated into a mechanistic model of homology search.

    • Jörg Renkawitz
    • , Claudio A. Lademann
    •  & Stefan Jentsch

    Series:

  • Review Article |

    Protein aggregation and amyloid deposition are associated with a wide range of medical disorders, including Alzheimer's disease and type II diabetes. Studies into the amyloid state are revealing fundamental principles that underlie the maintenance of protein homeostasis, and the origins of aberrant protein behaviour and disease.

    • Tuomas P. J. Knowles
    • , Michele Vendruscolo
    •  & Christopher M. Dobson
  • Review Article |

    Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape changes. Evidence suggests that the remodelling of cell junctions, especially adherens junctions (AJs), has major roles in controlling these behaviours. It is also clear that RHO GTPases and their effectors regulate actin polymerization and actomyosin contraction at AJs during epithelial reshaping.

    • Masatoshi Takeichi
  • Review Article |

    Although they are damaging when produced in large quantities, low levels of reactive oxygen species (ROS) can function within specific signalling pathways, based on the reversible oxidation of crucial Cys residues in reduction–oxidation (redox)-sensitive target proteins. Understanding these pathways has implications for metabolic regulation, innate immunity, stem cell biology, tumorigenesis and ageing.

    • Kira M. Holmström
    •  & Toren Finkel

Perspectives

    Essay

  • Essay |

    To mark the fiftieth anniversary of the European Molecular Biology Organization (EMBO), Gottfried Schatz reflects on the consequences of science growth, the challenges for young generations of researchers and on what EMBO has done for them.

    • Gottfried Schatz