Volume 15 Issue 5, May 2014

Volume 15 Issue 5

'Developing a pattern' by Vicky Summersby, inspired by the Review on p301.

Research Highlights


  • Review Article |

    As in animals, plant stem cells reside in stem cell niches, which produce signals that regulate the balance between self-renewal and differentiation into new tissues. Continuous organ production that is characteristic of plant growth requires a robust regulatory network to maintain this balance. Elucidating this network provides an opportunity to compare plant and animal stem cell strategies.

    • Renze Heidstra
    •  & Sabrina Sabatini
  • Review Article |

    The results of transcriptome-wide N6-methyladenosine (m6A) mapping techniques have resolved many of the long-standing concerns regarding the physiological relevance of m6A, which suggests that this modification regulates mRNA fate and function. The identification of adenosine methylases and demethylases provides insights into the cellular pathways that involve m6A and indicates a role of m6A in physiological processes.

    • Kate D. Meyer
    •  & Samie R. Jaffrey


  • Review Article |

    Advances over the past decade in the development of imaging probes, microscopy techniques and image analysis have enabled researchers to gain a deeper knowledge and understanding of the dynamic processes of embryonic differentiation, patterning and morphogenesis through quantitative whole-animal imaging studies with high spatiotemporal resolution.

    • Periklis Pantazis
    •  & Willy Supatto
  • Review Article |

    Epigenetic memory maintains gene expression states through cell generations, in the absence of the initiating signals or changes in DNA sequence. Our understanding of how the Polycomb (PcG) and Trithorax (TrxG) group proteins confer long-term, mitotically heritable memory by sustaining silent and active gene expression states, respectively, during DNA replication and mitosis, is increasing.

    • Philipp A. Steffen
    •  & Leonie Ringrose



  • Opinion |

    Dishevelled, EGL-10 and pleckstrin (DEP) domains carry out diverse functions by using different binding interfaces with well-defined structural features. It is becoming apparent that DEP domains mainly function in the spatial and temporal control of diverse signal transduction events by interacting with various partners at the plasma membrane.

    • Sarah V. Consonni
    • , Madelon M. Maurice
    •  & Johannes L. Bos