Volume 14 Issue 8, August 2013

Volume 14 Issue 8

'Mending broken hearts' by Vicky Summersby, inspired by the Review on p529.

Research Highlights


  • Progress |

    The extracellular matrix (ECM) is a key component of the stem cell niche and is now emerging as more than just an inert scaffold. Indeed, new technologies have provided mechanistic insights into the effects of the ECM on stem cell fate choice.

    • Fiona M. Watt
    •  & Wilhelm T. S. Huck


  • Review Article |

    The mechanisms that regulate miRNA stability and the generation of distinct miRNA isoforms are beginning to be elucidated. Better understanding of how such miRNAs mediate gene expression control will require quantitative analyses that dissect different models of miRNA function.

    • Stefan L. Ameres
    •  & Phillip D. Zamore
  • Review Article |

    Lineage-tracing and genetic labelling technologies, combined with statistical analyses of cell proliferation and clonal fate, provide powerful tools to study the mechanisms and dynamics of stem and progenitor cell fate determination in development and disease.

    • Cédric Blanpain
    •  & Benjamin D. Simons
  • Review Article |

    The ability of integrins to link the extracellular environment to intracellular networks enables cells to respond to chemical and physical cues. Insight has been gained into how talins and kindlins, two families of FERM-domain proteins that bind the cytoplasmic tail of integrins, mediate integrin activation and the cellular processes that depend on this.

    • David A. Calderwood
    • , Iain D. Campbell
    •  & David R. Critchley
  • Review Article |

    Recent work revealed new insights into the temporal regulation of G1–S cell cycle transcription, during proliferation and in response to activation of the DNA replication checkpoint. This has established the importance of G1–S transcription for both cell cycle progression and the maintenance of genome stability.

    • Cosetta Bertoli
    • , Jan M. Skotheim
    •  & Robertus A. M. de Bruin