Volume 14 Issue 7, July 2013

Volume 14 Issue 7

'Hedgehog signalling' by Vicky Summersby, inspired by the Review on p418.

Research Highlights

Reviews

  • Review Article |

    Cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization. The combination of structural data for filament severing with recently discovered mechanisms for cofilin activation in migrating cells is increasing our understanding of how cofilin activity affects cell behaviour.

    • Jose Javier Bravo-Cordero
    • , Marco A. O. Magalhaes
    • , Robert J. Eddy
    • , Louis Hodgson
    •  & John Condeelis
  • Review Article |

    The founding member of the Hedgehog (HH) family of secreted proteins was cloned two decades ago. The mechanism of HH signalling is incomplete, but insight has been gained into the function of lipidation in ligand secretion and transport, as well as into key components of the signalling pathway.

    • James Briscoe
    •  & Pascal P. Thérond
  • Review Article |

    Traditionally, the integrin activity status was thought to be regulated by activators (talin and kindlin), with integrins passively adopting an inactive state. However, it is now emerging that the integrin activity state is dynamically regulated, with inactivators (SHARPIN, ICAP1 and filamin) having a key role in dampening integrin function in different cellular contexts.

    • Daniel Bouvard
    • , Jeroen Pouwels
    • , Nicola De Franceschi
    •  & Johanna Ivaska

Perspectives

    Opinions

  • Opinion |

    The function and regulation of poly(ADP-ribosyl)ation is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation (MARylation) by ADP-ribosyl transferases. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes, and that specific macrodomain-containing proteins 'read' and 'erase' this modification.

    • Karla L. H. Feijs
    • , Alexandra H. Forst
    • , Patricia Verheugd
    •  & Bernhard Lüscher
  • Opinion |

    Early mammalian blastocyst patterning involves symmetry breaking leading to lineage segregation. The classic models of lineage segregation cannot account for recent experimental data, and a new framework that regards the early mammalian embryo as a self-organizing system is put forward to explain these observations.

    • Sebastian Wennekamp
    • , Sven Mesecke
    • , François Nédélec
    •  & Takashi Hiiragi