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Volume 14 Issue 4, April 2013

Research Highlight

  • mTOR regulates a Na+channel on endolysosomes; mTOR activity is regulated by DYRK3.

    • Katharine H. Wrighton
    Research Highlight

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  • DDX3 stimulates CK1ε kinase activity during WNT–β-catenin signalling.

    • Katharine H. Wrighton
    Research Highlight
  • Intestinal quiescent cells are committed to differentiate into secretory cells but can be called into stem cell action after injury.

    • Kim Baumann
    Research Highlight
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In Brief

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Research Highlight

  • Reactive oxygen species (ROS) are required for keratinocyte differentiation.

    • Rachel David
    Research Highlight
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In Brief

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Research Highlight

  • PLK1 dissociation from kinetochores is triggered by its ubiquitylation by CUL3–KLHL22.

    • Alison Schuldt
    Research Highlight
  • MASK is a novel and conserved component of the Hippo pathway that is required for Yorkie activity.

    • Andrea Du Toit
    Research Highlight
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Journal Club

  • The demonstration that senescence is caused by both telomere erosion and oncogene-induced accumulation of DNA damage at telomeres.

    • Jacqueline J. L. Jacobs
    Journal Club
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Review Article

  • Ataxia-telangiectasia mutated (ATM) is best known for its role in orchestrating the DNA damage response in response to double-strand breaks. However, it is now emerging that it is a far more versatile kinase, with roles in cell responses to other genotoxic stresses and in signalling pathways involved in cellular homeostasis.

    • Yosef Shiloh
    • Yael Ziv
    Review Article
  • The ability of signal transduction pathways to directly modify chromatin provides a means for rapid, and potentially long-lived, responses to environmental cues. Understanding how these modifications are stored on chromatin, integrated and interpreted should provide insight into the short- and long-term control of gene expression.

    • Aimee I. Badeaux
    • Yang Shi
    Review Article
  • During cell reprogramming and direct cell fate conversion, changes in somatic and pluripotent cell fates do not require the passage through a hierarchy of distinct cell fates that are proposed to occur during normal development and are consistent with the original Waddington model. Instead, a 'flat epigenetic disc' model might explain cell fate transitions during these processes.

    • Julia Ladewig
    • Philipp Koch
    • Oliver Brüstle

    Special:

    Review Article
  • Transcription-independent diffusible damage signals, such as Ca2+, H2O2and ATP, are generated immediately after epithelial wounding to alert tissues to damage. Together, these signals have short-term effects on actomyosin structures and immune cell chemotaxis, and in the longer term coordinate the subsequent transcription of specific wound response genes to direct the wound healing process.

    • João V. Cordeiro
    • António Jacinto
    Review Article
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