Volume 14 Issue 4, April 2013

Research Highlights

Reviews

  • Review Article |

    Ataxia-telangiectasia mutated (ATM) is best known for its role in orchestrating the DNA damage response in response to double-strand breaks. However, it is now emerging that it is a far more versatile kinase, with roles in cell responses to other genotoxic stresses and in signalling pathways involved in cellular homeostasis.

    • Yosef Shiloh
    •  & Yael Ziv

    Series:

  • Review Article |

    The ability of signal transduction pathways to directly modify chromatin provides a means for rapid, and potentially long-lived, responses to environmental cues. Understanding how these modifications are stored on chromatin, integrated and interpreted should provide insight into the short- and long-term control of gene expression.

    • Aimee I. Badeaux
    •  & Yang Shi
  • Review Article |

    During cell reprogramming and direct cell fate conversion, changes in somatic and pluripotent cell fates do not require the passage through a hierarchy of distinct cell fates that are proposed to occur during normal development and are consistent with the original Waddington model. Instead, a 'flat epigenetic disc' model might explain cell fate transitions during these processes.

    • Julia Ladewig
    • , Philipp Koch
    •  & Oliver Brüstle
  • Review Article |

    Transcription-independent diffusible damage signals, such as Ca2+, H2O2 and ATP, are generated immediately after epithelial wounding to alert tissues to damage. Together, these signals have short-term effects on actomyosin structures and immune cell chemotaxis, and in the longer term coordinate the subsequent transcription of specific wound response genes to direct the wound healing process.

    • João V. Cordeiro
    •  & António Jacinto